Diagnosis and treatment of diseases caused by mutations in CD72
OwnerBing Yanginventor
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Abstract
Mutants of the CD72 gene and their protein products are disclosed. Methods of diagnosing various diseases such as thyroid follicular carcinoma, renal cancer, endometrial adenocarcinoma, leukemia, ovarian cancer, lymphoma and lupus erythematosus by detecting particular mutations in human CD72 are also disclosed. Methods for supplying wild-type to cells which have lost normal CD72 function is additionally disclosed. CD72 associated diseases are additionally disclosed.
Claims72
A method of diagnosing cancer in an individual, comprising detecting a mutation in the human CD72 gene, mRNA or protein, wherein the presence of the mutation is indicative of cancer.
The method of claim 36, wherein the mutation results in a CD72 mRNA with a corresponding cDNA sequence of SEQ ID NO:10.
A method of diagnosing lupus erythematosus in an individual, comprising detecting a mutation in the human CD72 gene, mRNA or protein, wherein the presence of the mutation is indicative of lupus erythematosus.
An antibody specific for a mutant CD72 protein, wherein the antibody does not bind to normal CD72 protein.
A method of supplying wild-type CD72 gene function to a cell which has lost said gene function by virtue of a mutation in a CD72 gene, comprising:
- introducing a wild-type CD72 gene into a cell which has lost said gene function such that said wild-type CD72 gene is expressed in the cell.
A method of supplying wild-type CD72 gene function to a cell which has a mutation in a CD72 gene, comprising:
- introducing a portion of the wild-type CD72 gene into a cell which has lost said gene function such that said portion is expressed in the cell, said portion comprising a part of the wild-type CD72 gene which contains the mutation in the cell.
A method of supplying wild-type CD72 protein function to a cell which has lost said protein function by virtue of a mutation in a CD72 gene, comprising:
- introducing wild-type CD72 protein into a cell which has lost said protein function.
Dependencies are inferred from the claim text.