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OwnerDaniel T. Laskowitz, William D. Matthew +1inventors
InventorsDaniel T. Laskowitz, William D. Matthew, Michael McMillian
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Methods of suppressing the activation of microglial cells in the Central Nervous System (CNS), methods of ameliorating or treating the neurological effects of cerebral ischemia or cerebral inflammation, and methods of combating specific diseases that affect the CNS by administering a compound that binds to microglial receptors and prevents or reduces microglial activation are described. ApoE receptor binding peptides that may be used in the methods of the invention are also described, as are methods of using such peptides to treat peripheral inflammatory conditions such as sepsis. Also described are methods of screening compounds for the ability to suppress or reduce microglial activation.
A method of suppressing microglial activation, comprising exposing microglial cells to at least one compound that binds at a receptor bound by a peptide of ApoE in an amount effective to reduce microglial activation compared to that which would occur in the absence of the compound.
A method of suppressing microglial activation in a mammalian subject, comprising administering to the brain of said subject a compound or a composition comprising a compound that binds to microglial cells at a receptor bound by a peptide of ApoE, wherein said compound or composition is administered in an amount effective to reduce microglial activation compared to that which would occur in the absence of the compound.
A method of ameliorating symptoms associated with CNS inflammation in a subject, comprising administering to the brain of said subject a compound or a composition comprising a compound that binds to microglial cells at the receptor bound by a peptide of ApoE, said compound or composition is administered in an amount effective to reduce CNS inflammation compared to that which would occur in the absence of the compound.
A method of ameliorating symptoms associated with CNS ischemia in a subject, comprising administering to the brain of said subject a compound or a composition comprising a compound that binds to microglial cells at the receptor bound by a peptide of ApoE, said compound or composition is administered in an amount effective to reduce CNS ischemic compared to that which would occur in the absence of the compound.
A method of reducing neuronal cell injury associated with glutamate excitotoxicity in a mammalian subject by administering to said subject a compound or a composition comprising a compound that binds to microglial cells at the receptor bound by a peptide of ApoE, wherein said compound or composition is administered in an amount that reduces neuronal cell injury associated with glutamate excitotoxicity as compared to reduction that would occur in the absence of the compound.
The method of claim 32, wherein said anticonvulsant agent is selected from the group consisting of phenytoin, carbamazepine, valproic acid, lamotrigine, riluzole, tetrodotoxin, felbamate, gabapentin and ethosuximide.
A method of anesthesizing a subject comprising administering to said subject a compound or a composition comprising a compound that binds to the peptide that is bound by a peptide of ApoE, wherein said compound or composition is administered in an amount effect to anesthesize said subject.
A method of alleviating or reducing chronic pain in a subject comprising administering to said subject a compound or a composition comprising a compound that binds to a receptor that binds to a peptide of ApoE, wherein said compound or composition is administered in an amount that alleviates or reduces chronic pain in said patient.
A method of alleviating, correcting or preventing substance abuse in a subject comprising administering to said subject a compound or a composition comprising a compound that binds to a receptor that binds to a peptide of ApoE, wherein said compound or composition is administered in an amount effective to alleviate, correct or prevent substance abuse in said subject.
A method of suppressing macrophage activation in a mammalian subject, by administering to said subject a compound or a composition comprising a compound that binds to macrophage cells at the receptor bound by a peptide of ApoE, wherein said compound or composition is administered in an amount that suppresses macrophage activation as compared to activation that would occur in the absence of the compound.
A method of treating atherosclerosis or of reducing the formation of atherosclerotic plaques, comprising administering a compound or a composition containing a compound that binds to macrophage cells at the receptor bound by a peptide of ApoE, wherein the compound or composition is administered in an amount that reduces the formation of artherosclerotic plaques as compared to that which would occur in the absence of the compound.
A method of treating or of reducing the inflammation associated with sepsis in a subject, comprising administering a compound or a composition containing a compound that binds to a receptor that binds to a peptide of ApoE, where said compound or composition is administered in an amount that reduces sepsis-associated inflammation as compared to that which would occur in the absence of the compound.
A therapeutic composition comprising a peptide selected from the group consisting of SEQ ID NO:
A method of screening a test compound for the ability to suppress glial or microglial activation, comprising
A method of screening a test compound for the ability to prevent or suppress glial or microglial activation, comprising:
A method of screening a test compound for the ability to suppress glial or microglial activation, comprising
Dependencies are inferred from the claim text.