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OwnerLeonid A. Kozhemyakin, Mark B. Balasovskiinventors
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The present invention relates to a composite for the treatment of a variety of medical conditions, the composite comprising an oxidized glutathione-based compound, which has a disulfide bond, and a metal material, in particular where the metal is either platinum or palladium. The oxidized glutathione-based compound and metal material can be present in a ratio of 3000 to 1 and preferably 1000 to 1. The oxidized glutathione-based compound can be oxidized glutathione itself or salts or derivatives. A feature of the invention is that the composite has a more stabilized disulfide bond than the oxidized glutathione-based compound itself. Methods for preparing the composite are provided, such methods being beneficial in that the composite is provided in high yields and at high purity. Methods for treating various medical conditions with the composites of the present invention are also disclosed.
A composite comprising an oxidized glutathione-based compound and a metal material in a molar equivalent ratio of between about 3000:1 to about 1:1, wherein the metal material comprises a metal selected from the group consisting of platinum and palladium.
A method for stabilizing a disulfide bond of an oxidized glutathione-based compound, comprising interacting the oxidized glutathione-based compound with a material comprising platinum.
A method of stimulating endogenous production of cytokines and hemopoietic factors comprising introducing to a mammalian body in need of stimulation of cytokines or hemopoietic factors or both, an effective amount of a composite comprising an oxidized glutathione-based compound and a metal material in a molar equivalent ratio of between about 3000:1 to about 1:1 wherein the metal material comprises a metal selected from the group consisting of platinum and palladium, for a period of time to stimulate said endogenous production to obtain a therapeutic effect for a disease.
A method of enhancing and prolonging the ability of an oxidized glutathione-based compound to stimulate endogenous production of cytokine and hemopoietic factors, said method comprising interacting the oxidized glutathione-based compound with a metal material in a molar equivalent ratio of between about 3000:1 to about 1:1 wherein the metal material comprises a metal selected from the group consisting of platinum and palladium.
A method for treating a subject having a disease, comprising:
The method of claim 120, wherein said normal and transformed cells are in a mammalian body and said composite is introduced into said body at a rate of from about 0.01 mg/kg to about 1.0 mg/kg of body weight at least one time a day for at least one day.
The method of claim 120, wherein said normal and transformed cells are in a mammalian body and said composite is introduced topically to a topical area at a dose of from about 1.0 mg/m2 to about 100 mg/m2 of topical area.
A composite comprising an oxidized glutathione-based compound comprising a carbon/nitrogen backbone of each of a dimer of a glutamic acid bonded to a cysteine bonded to a glycine, the dimer being linked through a disulfide unit, said composite further comprising a metal material in a molar equivalent ratio of between about 3000:1 to about 1:1, wherein the metal material comprises a metal selected from the group consisting of platinum and palladium.
Dependencies are inferred from the claim text.