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US 2003/0077280 A1Published application
5c8 Antigen
AssigneeThe Trustees of Columbia University in the City of New York
InventorsSeth Lederman, Leonard Chess, Michael J. Yellin
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AssigneeThe Trustees of Columbia University in the City of New York
InventorsSeth Lederman, Leonard Chess, Michael J. Yellin
Estimating the term…
This invention provides a monoclonal antibody which specifically recognizes and forms a complex with a protein located on the surface of activated T cells and thereby inhibits T cell activation of B cells. This invention also provides the monoclonal antibody 5c8 (ATCC Accession No. ______). This invention provides a human CD4− T cell leukemia cell line designated D1.1 (ATCC Accession No. ______) capable of constitutively providing contact-dependent helper function to B cells. This invention also provides an isolated protein from the surface of activated T cells, wherein the protein is necessary for T cell activation of B cells. This invention further provides an isolated, soluble protein from the surface of activated T cells, wherein the protein is necessary for T cell activation of B cells.
A monoclonal antibody which specifically recognizes and forms a complex with a protein located on the surface of activated T cells and thereby inhibits T cell activation of B cells.
The monoclonal antibody 5c8 (ATCC Accession No.
A hybridoma cell of claim 34, wherein the hybridoma cell produces monoclonal antibody 5c8 (ATCC Accession No. ______).
A human CD4− T cell leukemia cell line designated D1.1 (ATCC Accession No. ______) capable of constitutively providing contact-dependent helper function to B cells.
An isolated protein from the surface of activated T cells, wherein the protein is necessary for T cell activation of B cells.
An isolated, soluble protein from the surface of activated T cells, wherein the protein is necessary for T cell activation of B cells.
The monoclonla antibody produced by the method of claim 70.
A method of immunizing an animal against a protein antigen which comprises:
Dependencies are inferred from the claim text.