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AssigneesMedtronic AVE, Inc., United States of America
InventorsAnthony L. Fitzhugh, Robert Cafferata, Larry K. Keefer
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Extremely hydrophobic nitric oxide (NO) releasing polymers are disclosed. The extremely hydrophobic NO-releasing polymers provided are extensively cross-linked polyamine-derivatized divinylbenzene diazeniumdiolates. These polymers can be loaded with extremely high NO levels and designed to release NO in manners than mimic natural biological systems. The NO-releasing extremely hydrophobic polymers provided can maintain a sustained NO release for periods exceeding nine months. Also provided are related medical devices made using these NO-releasing extremely hydrophobic polymers.
Highly cross-linked, extremely hydrophobic nitric oxide-releasing biocompatible polydiazeniumdiolated polyamine-functionalized polymers.
A highly cross-linked, extremely hydrophobic nitric oxide releasing biocompatible polymer wherein said biocompatible polymer is a polyamine derivatized form of polydivinylbenzene having the general formula:
A method for treating ischemia in a human or an animal comprising:
A method for treating infections in a human or an animal wherein said highly cross-linked, extremely hydrophobic nitric oxide-releasing biocompatible polydiazeniumdiolated polymer comprises a stent, trocar, guide wire, tampon, sanitary napkin, wound dressing/bandage, vascular graft, sutures, and the like.
A method that prevents blood coagulation and maintains an aseptic environment during blood transfusions, hemodialysis, and the administration of other blood components via tubing for a human or an animal comprising:
A method for storing mammalian blood thrombocytes comprising a collection and storage device that prevents blood coagulation and maintains an aseptic environment for human or animal blood comprising:
Dependencies are inferred from the claim text.