Immunoglobulin E vaccines and methods of use thereof
AssigneeSwey-Shen Alex Chen
InventorsSwey-Shen Alex Chen, Yong-Min Yang, Theresa J. Barankiewicz, Zhong Chen
Life of this patent
Estimating the term…
Abstract
The present invention concerns the prophylaxis or therapy of immunoglobulin E-mediated disease conditions. The present invention discloses methods for identifying peptides that induce a cytotoxic T-lymphocyte response against immunoglobulin E. The present invention further discloses compositions that are able to elicit in a mammal a cytotoxic T-lymphocyte response to naturally processed and presented immunoglobulin E peptides, and methods for their use.
Claims138
A method of identifying peptides that induce a cytotoxic T-lymphocyte response against immunoglobulin E, comprising:
- a. providing at least one test peptide suspected of being able to bind to at least one major histocompatibility complex class I molecule, and
- b. evaluating said at least one test peptide for the ability to elicit in a mammal a cytotoxic T-lymphocyte response to naturally processed and presented immunoglobulin E peptides,
- wherein a peptide that induces such a response is identified.
A method of modulating an immunoglobulin E-mediated condition in a mammal, comprising providing to said mammal a composition that elicits in said mammal a cytotoxic T-lymphocyte response to naturally processed and presented immunoglobulin E peptides, in an amount sufficient to elicit said cytotoxic T-lymphocyte response in said mammal.
Dependencies are inferred from the claim text.