65577, a human matrix metalloproteinase and uses therefor
AssigneeMillennium Pharmaceuticals, Inc.
InventorRajasekhar Bandaru
Life of this patent
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Abstract
The invention provides isolated nucleic acids molecules, designated 65577 nucleic acid molecules, which encode matrix metalloproteinases. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 65577 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a 65577 gene has been introduced or disrupted. The invention still further provides isolated 65577 proteins, fusion proteins, antigenic peptides and anti-65577 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
Claims33
An isolated nucleic acid molecule selected from the group consisting of:
- a. a nucleic acid molecule comprising a nucleotide sequence which is at least 80% identical to the nucleotide sequence of SEQ ID NO:
- 1 or SEQ ID NO:
- 3;
- b. a nucleic acid molecule comprising a fragment of at least 750 nucleotides of the nucleotide sequence of SEQ ID NO:
- 1 or SEQ ID NO:
- 3;
- c. a nucleic acid molecule which encodes a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2;
- d. a nucleic acid molecule which encodes a fragment of a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2, wherein the fragment comprises at least 320 contiguous amino acids of SEQ ID NO:
- 2;
- and
- e. a nucleic acid molecule which encodes a naturally occurring allelic variant of a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2, wherein the nucleic acid molecule hybridizes to a nucleic acid molecule comprising SEQ ID NO:
- 1 or 3, or a complement thereof, under stringent conditions.
An isolated polypeptide selected from the group consisting of:
- a. a polypeptide which is encoded by a nucleic acid molecule comprising a nucleotide sequence which is at least 80% identical to a nucleic acid comprising the nucleotide sequence of SEQ ID NO:
- 1 or SEQ ID NO:
- 3, or a complement thereof;
- b. a naturally occurring allelic variant of a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2, wherein the polypeptide is encoded by a nucleic acid molecule which hybridizes to a nucleic acid molecule comprising SEQ ID NO:
- 1 or SEQ ID NO:
- 3;
- and
- c. a fragment of a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2, wherein the fragment comprises at least 100 contiguous amino acids of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.