Novel mammalian secreted group IIF phospholipase A2
AssigneeCentre National De La Recherche Scientique (Cnrs)
InventorsMichel Lazdunski, Gerard Lambeau, Emmanuel Valentin
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Abstract
The invention concerns DNA and peptide sequences encoding a novel mammalian secreted group IIF phospholipase A2 wherein said enzyme is Ca2+-dependent, maximally active at pH 7-8, and hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference and more particularly, a novel human group IIF phospholipase A2. The invention also concerns the use of this enzyme in methods for screening various chemical compounds.
Claims19
A mammalian secreted group IIF sPLA2 which is Ca2+-dependent, maximally active at pH of about 7-8, and hydrolyzes phosphatidylglycerol versus phosphatidylcholine with about a 15-fold preference.
A nucleic acid molecule comprising an encoding nucleic sequence for a mammalian secreted group IIF sPLA2 or for a fragment of a mammalian secreted group IIF sPLA2 having SEQ ID No2.
Dependencies are inferred from the claim text.