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US 2003/0069447 A1Published application
Acetal hydroxylamine compounds
OwnerPaul Howard Briner, Andrew Floodinventors
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Abstract
Compounds of formula (I): R1CH2(OR2)ONH2, wherein R1 is hydrogen or methyl and R2 is a C1-C6 alkyl group, or a salt thereof are useful as reagents for the synthesis of biologically active hydroxyaminocarbonyl- and N-formyl-N-hydroxylamino-containing compounds.
Claims12
A compound of formula (I)
- R1CH2CH(OR2)ONH2 (I)
- wherein R1 is hydrogen or methyl and R2 is a C1-C6 alkyl group, or a salt thereof
O-(1-Butoxy-ethyl)-hydroxylamine or a salt thereof.
O-(1-Isobutoxy-ethyl)-hydroxylamine or a salt thereof.
A process for the preparation of compounds containing an N-substituted β-lactam moiety of formula (V)
- 24
- which comprises reaction of a compound containing a 1-carboxy-2-hydroxy-1-yl moiety of formula (VA)
- 25
- with a compound of the invention (I) thereby converting moiety (VA) to a moiety (VB)
- 26
- then cyclising moiety (VB) by internal amino-hydroxyl condensation to form the desired N-substituted β-lactam compound (V).
3 more elements
Dependencies are inferred from the claim text.