Compositions including modafinil for treatment of attention deficit hyperactivity disorder and multiple sclerosis fatigue
AssigneeCephalon, Inc.
InventorsMatthew S. Miller, Thomas E. Scammell
Life of this patent
Estimating the term…
Abstract
Modafinil is effective in improving symptoms of attention deficit hyperactivity disorder and symptoms of multiple sclerosis fatigue. The administration of modafinil is also shown to activate the tuberomamillary neurons of the posterior hypothalamus, and thus exhibits activity in an area of the brain associated with normal wakefulness functions.
Claims32
A method of treating attention deficit hyperactivity disorder comprising administering to a subject suffering from or susceptible to the development of attention deficit hyperactivity disorder a composition comprising a modafinil compound in an amount effective to improve or prevent symptoms of attention deficit hyperactivity disorder in said subject.
A method of treating fatigue associated with multiple sclerosis comprising administering to a subject suffering from multiple sclerosis fatigue a composition comprising a modafinil compound in an amount effective to improve or prevent symptoms of multiple sclerosis fatigue in said subject.
A method of treating a subject suffering from the symptoms of attention deficit hyperactivity disorder or multiple sclerosis fatigue comprising administering to said subject a pharmaceutical composition comprising a modafinil compound in an amount effective to stimulate activity in the tuberomamillary neurons of the brain of said subject.
A pharmaceutical composition in unit dose form, for use in treating attention deficit hyperactivity disorder in a subject susceptible to the development of or suffering from attention deficit hyperactivity disorder, which comprises:
- an amount of a modafinil compound such that one or more unit doses thereof are effective to stabilize or improve the symptoms of attention deficit hyperactivity disorder in said subject upon periodic administration.
A pharmaceutical composition in unit dose form, for use in treating fatigue in a multiple sclerosis patient, which comprises:
- an amount of a modafinil compound such that one or more unit doses thereof are effective to stabilize or improve the symptoms of multiple sclerosis fatigue in said patient upon periodic administration.
A therapeutic package for dispensing to, or for use in dispensing to, a mammal being treated for attention deficit hyperactivity disorder, comprising:
- (1) one or more unit doses, each such unit dose containing an amount of a modafinil compound such that said one or more unit doses thereof are effective to stabilize or improve a symptom of attention deficit hyperactivity disorder in said mammal upon periodic administration and the unit doses being administered periodically;
- and
- (2) a finished pharmaceutical container therefor,
- said container containing said unit dose or unit doses and labeling directing the use of said package in the treatment of said mammal.
A therapeutic package for dispensing to, or for use in dispensing to, a mammal being treated for multiple sclerosis fatigue, comprising:
- (1) one or more unit doses, each such unit dose containing an amount of a modafinil compound such that said one or more unit doses thereof are effective to stabilize or improve a symptom of multiple sclerosis fatigue in said mammal upon periodic administration and the unit doses being administered periodically;
- and
- (2) a finished pharmaceutical container therefor,
- said container containing said unit dose or unit doses and labeling directing the use of said package in the treatment of said mammal.
A method of identifying a compound that selectively modulates activity of the tuberomamillary nucleus of the posterior hypothalamus comprising the steps of:
- (a) contacting a tuberomamillary nucleus with a test compound;
- and
- (b) determining activity of said tuberomamillary nucleus,
- wherein a change in activity of the neurons of said nucleus is indicative of a modulator.
Dependencies are inferred from the claim text.