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AssigneeChemokine Therapeutics Corporation
InventorsGeeta Saxena, Christopher R. Tudan, Hassan Salari
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The invention provides therapeutic and biological uses of chemokine-receptor-binding compounds (including chemokine receptor ligands such as chemokine receptor agonists or antagonists), such as tricyclic phenanthrene derivatives, including uses in the treatment of disease states mediated by chemokines. The relevant chemokines may for example be monocyte chemoattractant protein-one (MCP-1) or interleukin-8 (IL-8), and the relevant chemokine receptors may for example be corresponding chemokine receptors (CCR-2, CCR-4, CXCR-1, and CXCR-2). In other aspects, the invention provides corresponding pharamaceutical compositions and therapeutic methods. In one aspect, for example, the invention provides for the use of phenanthrene-9,10-dione in the treatment of multiple sclerosis.
The use of a compound of formula (I), (II), (III) or (IV), or a pharmaceutically acceptable salt thereof, to formulate a medicament for the treatment of a chemokine mediated disease state:
The use of a compound of formula (I), (II), (III) or (IV), or a pharmaceutically acceptable salt thereof, to treat a chemokine mediated disease state:
A method of treating a chemokine mediated disease state in a mammal in need of such treatment, which comprises administering to the mammal an effective amount of a compound of the formula (I), (II), (III) or (IV), or a pharmaceutically acceptable salt thereof:
A method of inhibiting the interaction of a chemokine with a chemokine receptor (Chemokine antagonist) in a mammal, comprising administering to the mammal an effective amount of a compound of formula (I), (II), (III) or (IV), or a pharmaceutically acceptable salt thereof:
A method of inhibiting the interaction of a chemokine with a chemokine receptor (Chemokine antagonist) in a mammal, comprising administering to the mammal an effective amount of a compound of formula (I), (II), (III) or (IV), or a pharmaceutically acceptable salt thereof:
The use of a compound of formula (I), (II), (III) or (IV), or a pharmaceutically acceptable salt thereof, as an active pharmaceutical substance:
A pharmaceutical composition comprising a compound of formula (I), (II), (III) or (IV), or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, excipient or diluent:
The use of a compound to formulate a medicament for the treatment of a chemokine mediated disease state, wherein the compound has the following formula:
Dependencies are inferred from the claim text.