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AssigneeCytovia, Inc.
InventorsSui Xiong Cai, John A. Drewe, P. Sanjeeva Reddy, Bao Nguyen, Azra Pervin
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The present invention is directed to substituted 2-aryl-4-arylaminopyrimidine and analogs thereof, represented by the general Formula I: 1 wherein A, Ar1, Ar2, R1 and R3 are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. The compounds of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
A method of treating a disorder responsive to the induction of apoptosis in an animal suffering therefrom, comprising administering to an animal in need of such treatment an effective amount of a compound of Formula I:
A method for treating or preventing cancer, comprising administering to an animal in need of such treatment an effective amount of a compound of Formula I:
A method for the treatment of drug resistant cancer, comprising administering to an animal in need of such treatment an effective amount of a compound of the Formula I:
A compound selected from the group consisting of:
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of Formula I:
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound selected from the group consisting of:
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound selected from the group consisting of:
Dependencies are inferred from the claim text.