Alpha (1,3) galactosyl transferase negative swine
AssigneeThe General Hospital Corporation
InventorsKenth T. Gustafsson, David H. Sachs, Manfred W. Baetscher
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Abstract
Transgenic swine in which the normal expression of α(1,3) galactosyltransferase is prevented in at least one organ of tissue type. The absence or inactivation of this enzyme prevents the production of carbohydrate moieties having the distinctive terminal Galα1-3Galβ1-4GlcNAc epitope that is a significant factor in xenogeneic, particularly human, transplant rejection of swine grafts.
Claims18
A transgenic swine is which the normal expression of the α(1,3) galactosyltransferase is prevented in at least one organ or tissue type.
An α(1,3) galactosyltransferase negative swine grown from a porcine oocyte whose pronuclear material has been removed and into which has been introduced a pluripotent porcine embryonic stemcell that is negative for the expression of α(1,3) galactosyltransferase
A nucleic acid having a sequence selected from the group consisting of SEQ. ID. NOS. 1 and 13 through 24.
Dependencies are inferred from the claim text.