Treatment of sleep disturbances
OwnerGraham D. Cook, Todd S. Koch +5inventors
InventorsGraham D. Cook, Todd S. Koch, David H. Giamalva, Justin Bianco, James J. Fort, Geraldine Doyle, Steven Cooper
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Abstract
The present invention provides a new composition for treating pain-associated sleep disturbances, especially shortened sleep duration, comprising ibuprofen and diphenhydramine. The composition is further prepared as a bilayer tablet or caplet, or alternatively as a soft gelatin capsule composition, to prevent interaction between the active ingredients.
Claims25
A composition comprising ibuprofen and diphenhydramine in amounts effective to treat a pain-associated sleep disturbance, wherein the composition is formulated to prevent negative interactions between the diphenhydramine and the ibuprofen.
A method of evaluating a compound or composition for the treatment of a pain-associated sleep disturbance, wherein
- a) a compound or composition is administered to a patient after oral surgery;
- b) the patient is required to go to bed earlier than said patient's usual bedtime;
- and
- c) and the effectiveness of the compound or composition is assessed.
Dependencies are inferred from the claim text.