MR signal-emitting coatings
AssigneeWisconsin Alumni Research Foundation
InventorsRichard Frayne, Charles M. Strother, Orhan Unal, Zhihao Yang, Abukar Wehelie, Hyuk Yu
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Abstract
The present invention provides a coating that emits magnetic resonance signals and a method for coating medical devices therewith. The coating includes a paramagnetic metal ion-containing polymer complex that facilitates diagnostic and therapeutic techniques by readily visualizing medical devices coated with the complex.
Claims19
A magnetic resonance imaging system, comprising:
- a magnetic resonance device for generating a magnetic resonance image of a target object in an imaging region;
- and
- an instrument for use with the target object in the imaging region, said instrument including a body sized for use in the target object and a polymeric-paramagnetic ion complex coating thereon in which said complex is represented by formula (I):
- P-X-L-Mn+ (I)
- wherein P is a polymer, X is a surface functional group, L is a chelate, M is a paramagnetic ion and n is an integer that is 2 or greater.
A coating for visualizing medical devices in magnetic resonance imaging, comprising a complex of formula (I):
- P-X-L-Mn+ (I)
- wherein P is a polymer, X is a surface functional group, L is a chelate, M is a paramagnetic ion and n is an integer that is 2 or greater.
A coating for visualizing medical devices in magnetic resonance imaging, comprising a complex of formula (II):
- P-X-J-L-Mn+ (II)
- wherein P is a polymer, X is a surface functional group, L is a chelate, M is a paramagnetic ion, n is an integer that is 2 or greater and J is the linker or spacer molecule.
A method for visualizing medical devices in magnetic resonance imaging, comprising:
- (a) coating the medical device with a polymeric-paramagnetic complex of formula (I):
- P-X-L-Mn+ (I)
- wherein P is a polymer, X is a surface functional group, L is a chelate, M is a paramagnetic ion and n is an integer that is 2 or greater.
- (b) positioning the device within a target object;
- and
- (c) imaging the target object and coated device.
An magnetic resonance (MR)-emitting coating, comprising a paramagnetic ion-containing polymer.
A method of visualizing medical devices in magnetic resonance imaging, comprising coating the devices with a paramagnetic ion-containing polymer.
Dependencies are inferred from the claim text.