Adsorbing and non-adsorbing surfaces for biological materials
OwnerJerome J. Cuomo, Vinay Sakrani +1inventors
InventorsJerome J. Cuomo, Vinay Sakrani, Stefan Ufer
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Abstract
A substrate having a chemically modified surface comprises a base layer having a coating positioned thereon. The coating includes a chemically crosslinked material comprising elements selected from the group consisting of (1) M, O, C, H, and N; wherein M is a metal selected from the group consisting of silicon, titanium, tantalum, germanium, boron, zirconium, aluminum, hafnium and yttrium, (2) M, O, H, and N wherein M is defined above, (3) C, (4) O, C, H, and N, and (5) M or C and one of O, H, or N, wherein the chemically crosslinked material is terminated with at least one electrophilic or nucleophilic functional group.
Claims43
A substrate having a chemically modified surface, said substrate comprising a base layer having a coating positioned thereon, the coating comprising a chemically crosslinked material comprising elements selected from the group consisting of (1) M, O, C, H, and N;
- wherein M is a metal selected from the group consisting of silicon, titanium, tantalum, germanium, boron, zirconium, aluminum, hafnium and yttrium;
- (2) M, O, H, and N wherein M is defined above, (3) C;
- (4) O, C, H, and N;
- and (5) M or C, and one of O, H, or N, wherein the chemically crosslinked material is terminated with at least one electrophilic or nucleophilic functional group.
The microfluidic system according to claim 32, wherein the system comprises at least one biofouling surface.
A method of chemically modifying a surface on a substrate, said method comprising:
- exposing a composition comprising at least one precursor to an energy source to form a energized precursor;
- promoting the energized precursor into an excited state to produce ionic materials;
- depositing the ionic materials on a base layer such that the ionic materials form a coating thereon, the coating comprising a chemically crosslinked material comprising elements selected from the group consisting of (1) M, O, C, H, and N;
- wherein M is a metal selected from the group consisting of silicon, titanium, tantalum, germanium, boron, zirconium, aluminum, hafnium and yttrium;
- (2) M, O, H, and N wherein M is defined above, (3) C;
- (4) O, C, H, and N;
- and (5) M or C, and one of O, H, or N;
- and
- treating the chemically crosslinked material such that the material is terminated with at least one electrophilic or nucleophilic functional group.
Dependencies are inferred from the claim text.