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US 2002/0172721 A1Published application
Vitamin formulation for cardiovascular health
AssigneeBristol-Myers Squibb Company
InventorsAtef Boulos, Jatin Desai, Neil Martin, Robert Stillman, Marion Udwin
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Abstract
The invention concerns a composition containing a high level of Vitamin E in encapsulated form, preferably as beadlets or spray dried, and a high level of silicates. The composition is compressible into tablets or caplets that do not leach out Vitamin E into the tablet matrix during compression and/or storage. The composition preferably contains vitamins and minerals in doses optimized for cardiovascular health.
Claims14
A composition comprising:
- (i) an amount of encapsulated Vitamin E such that when the composition is divided into unit doses each unit dose contains at least 100 IU Vitamin E,
- (ii) from about 0.5% to about 10% by weight based on total weight of the composition, of precipitated silica,
- (iii) from about 1% to about 10% by weight, based on total weight of the composition, of calcium silicate,
- (iv) from about 5% to about 50% by weight, based on total weight of the composition, of microcrystalline cellulose,
- (v) from 0 to about 5% by weight, based on total weight of the composition, of talc;
- the precipitated silica and the calcium silicate being present in a total amount of over 4% by weight, based on total weight of the composition;
- the encapsulated Vitamin E and the total amount of silica and calcium silicate being present in a ratio of from 3:1 to 6:1;
- and the composition being compressible into stable tablet or caplet unit doses.
5 more elements
Dependencies are inferred from the claim text.