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US 2002/0165159 A1Published application
FSH-releasing peptides
AssigneeBoard of Supervisors of Louisiana State University and Agricultural and Mechanical College
InventorsSamuel M. McCann, Wen H. Yu
Life of this patent
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Abstract
Lamprey LHRH-III is a potent FSH-releasing factor, and may be used to enhance fertility. Antagonists to lamprey LHRH-III may be used to inhibit fertility.
Claims77
A method of altering the level of secretion of FSH in a vertebrate animal, comprising administering to the animal an effective amount of a peptide selected from the group consisting of an l-LHRH-III agonist peptide;
- an l-LHRH-III superagonist peptide;
- an l-LHRH-III antagonist peptide;
- a peptide selected from the group consisting of SEQ. ID NO. 6 through SEQ. ID NO. 41;
- and l-LHRH-III (SEQ. ID NO. 1);
- wherein the amount of the peptide administered causes a selective change in the serum FSH level of the animal, but does not cause a proportional change in the serum LH level of the animal.
2 more elements
A composition selected from the group consisting of an l-LHRH-III agonist peptide;
- an l-LHRH-III superagonist peptide;
- an I-LHRH-III antagonist peptide;
- a peptide selected from the group consisting of SEQ. ID NO. 6 through SEQ. ID NO. 41;
- and an effective amount of substantially pure l-LHRH-III (SEQ. ID NO. 1) admixed with a pharmaceutically acceptable carrier;
- wherein said composition has the property that said composition will, when administered in an effective amount to a vertebrate animal, cause a selective change in the serum FSH level of the animal, but will not cause a proportional change in the serum LH level of the animal.
2 more elements
Dependencies are inferred from the claim text.