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OwnerDerek Van Der Kooy, Vincent Tropepeinventors
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Described are a novel cell type in the neural lineage, and method of producing the same based on the degree of neural commitment and growth factor responsiveness in vitro and the potential to give rise to neural and non-neural progeny in vivo. The novel veil type of neural lineage and cells derived therefrom have a number of applications including applications regarding tissue engineering, transplantation and gene therapy and drug discovery. Also described are suggested uses of the method and cell type including isolating genes that positively and negatively regulate the transmission from an ES cell to a neural cell and generally for studying ES cell models of mammalian neural development.
A method for differentiating one or more pluripotent embryonic stem (ES) cells toward one or more neural cells comprising:
A method for producing secondary neural stem cell colonies comprising:
One or more cell(s) expressing one or more neural precursor cell marker(s) and/or one or more neural-specific mRNA molecule(s), and having multilineage potential.
A primitive neural stem cell produced comprising at least one neural cell marker and is pluripotent.
A method for screening for modulators of cellular differentiation comprising
A method for screening for differentiation factors of cellular development comprising:
Dependencies are inferred from the claim text.