Methods of suppressing microglial activation
AssigneeCognosci, Inc.
InventorsDaniel T. Laskowitz, William D. Matthew, Michael McMillian
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Abstract
Methods of suppressing the activation of microglial cells in the Central Nervous System (CNS), methods of ameliorating or treating the neurological effects of cerebral ischemia or cerebral inflammation, and methods of combating specific diseases that affect the CNS by administering a compound that binds to microglial receptors and prevents or reduces microglial activation are described. Also described are methods of screening compounds for the ability to suppress or reduce microglial activation.
Claims13
A method of suppressing microglial activation in a mammalian subject, comprising administering to the brain of said subject a compound that binds to microglial cells at the receptor bound by a peptide of SEQ ID NO:3 (the LRP/α2M receptor), said compound administered in an amount effective to reduce microglial activation compared to that which would occur in the absence of the compound.
A method of ameliorating symptoms associated with CNS inflammation in a subject, comprising administering to the brain of said subject a compound that binds to microglial cells at the receptor bound by a peptide of SEQ ID NO:3 (the LRP/α2M receptor), said compound administered in an amount effective to reduce microglial activation compared to that which would occur in the absence of the compound.
A method of ameliorating symptoms associated with CNS ischemia in a subject, comprising administering to the brain of said subject a compound that binds to microglial cells at the receptor bound by a peptide of SEQ ID NO:3 (the LRP/α2M receptor), said compound administered in an amount effective to reduce microglial activation compared to that which would occur in the absence of the compound.
Dependencies are inferred from the claim text.