Nucleic acid molecules, polypeptides and uses therefor, including diagnosis and treatment of alzheimer's disease

A preparation comprising an isolated human protein, said protein comprising a tryptic digest peptide having the following partial sequence as determined by mass spectrometry:

• PGLGM.

A preparation comprising an isolated human protein, said protein comprising a tryptic digest peptide having the following partial sequence as determined by mass spectroscopy:

• GPLGM.

A preparation comprising an isolated human protein, said protein comprising a tryptic digest peptide having the following partial sequence as determined by mass spectroscopy:

• PGLGF.

A preparation comprising an isolated human protein, said protein comprising a tryptic digest peptide having the following partial sequence as determined by mass spectroscopy:

• GPLGF.

A preparation comprising an isolated human protein, said protein comprising a tryptic digest peptide having the following partial sequence as determined by mass spectrometry:

• PGIGM.

A preparation comprising an isolated human protein, said protein comprising a tryptic digest peptide having the following partial sequence as determined by mass spectroscopy:

• GPIGM.

A preparation comprising an isolated human protein, said protein comprising a tryptic digest peptide having the following partial sequence as determined by mass spectroscopy:

• PGIGF.

A preparation comprising an isolated human protein, said protein comprising a tryptic digest peptide having the following partial sequence as determined by mass spectroscopy:

• GPIGF.

A preparation comprising an isolated human protein, said protein comprising a tryptic digest peptide having the following partial sequence as determined by mass spectroscopy:

• HQV.

An isolated nucleic acid molecule that hybridizes to a nucleotide sequence encoding API-111, a nucleotide sequence encoding API-112, or their complements.

An isolated nucleic acid molecule that hybridizes to a nucleotide sequence encoding at least 10 consecutive amino acids of API-111 a nucleotide sequence encoding at least 10 consecutive amino acids of API-112, or their complements.

An isolated nucleic acid molecule that hybridizes under highly stringent conditions or moderately stringent conditions to the following nucleic acid sequence:

• CCNGGNYTNGGNATG.

An isolated nucleic acid molecule that hybridizes under highly stringent conditions or moderately stringent conditions to the following nucleic acid sequence:

• GGNCCNYTNGGNATG.

An isolated nucleic acid molecule that hybridizes under highly stringent conditions or moderately stringent conditions to the following nucleic acid sequence:

• CCNGGNYTNGGNTTY.

An isolated nucleic acid molecule that hybridizes under highly stringent conditions or moderately stringent conditions to the following nucleic acid sequence:

• GGNCCNYTNGGNTTY.

An isolated nucleic acid molecule that hybridizes under highly stringent conditions or moderately stringent conditions to the following nucleic acid sequence:

• CCNGGNATHGGNATG.

An isolated nucleic acid molecule that hybridizes under highly stringent conditions or moderately stringent conditions to the following nucleic acid sequence:

• CCNGGNATHGGNTTY.

An isolated nucleic acid molecule that hybridizes under highly stringent conditions or moderately stringent conditions to the following nucleic acid sequence:

• GGNCCNATHGGNATG.

An isolated nucleic acid molecule that hybridizes under highly stringent conditions or moderately stringent conditions to the following nucleic acid sequence:

• GGNCCNATHGGNTTY.

An isolated nucleic acid molecule that hybridizes under highly stringent conditions or moderately stringent conditions to the following nucleic acid sequence:

• CCCGGCCTGGGCATG.

An isolated nucleic acid molecule that hybridizes under highly stringent conditions or moderately stringent conditions to the following nucleic acid sequence:

• GGCCCCCTGGGCATG.

An isolated nucleic acid molecule that hybridizes under highly stringent conditions or moderately stringent conditions to the following nucleic acid sequence:

• CCCGGCCTGGGCTTC.

An isolated nucleic acid molecule that hybridizes under highly stringent conditions or moderately stringent conditions to the following nucleic acid sequence:

• GGCCCCCTGGGCTTC.

An isolated nucleic acid molecule that hybridizes under highly stringent conditions or moderately stringent conditions to the following nucleic acid sequence:

• CCCGGCATCGGCATG.

An isolated nucleic acid molecule that hybridizes under highly stringent conditions or moderately stringent conditions to the following nucleic acid sequence:

• CCCGGCATCGGCTTC.

An isolated nucleic acid molecule that hybridizes under highly stringent conditions or moderately stringent conditions to the following nucleic acid sequence:

• GGCCCCATCGGCATG.

An isolated nucleic acid molecule that hybridizes under highly stringent conditions or moderately stringent conditions to the following nucleic acid sequence:

• GGCCCCATCGGCTTC.