Mammalian glycoprotein hormone-1
OwnerJames L. Holloway, Philippa J. Webster +1inventors
InventorsJames L. Holloway, Philippa J. Webster, Edward C. Thayer
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Abstract
Mammalian glycoprotein hormone-1 (Zlut1) polypeptides, polynucleotides encoding the polypeptides, antibodies that specifically bind to the polypeptides, expression vectors comprised of the polynucleotides, and host cells transformed with the expression vectors.
Claims6
An isolated polynucleotide, wherein said polynucleotide encodes a polypeptide comprised of an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 2, 9, 10, 11, 12, 13 and 14.
An isolated polypeptide, wherein said polypeptide is comprised of an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 2, 9, 10, 11, 12, 13 and 14.
An isolated antibody, wherein said antibody specifically binds to an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 2, 9, 10, 11, 12, 13 and 14.
A method for treating hyperthyroidism in female mammals comprising administering to a female mammal afflicted with hyperthyroidism a polypeptide, wherein said polypeptide is comprised of an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 2, 9, 10, 11, 12, 13 and 14.
A pharmaceutical comprosition comprised of a polypeptide, wherein said polypeptide is comprised of an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 2, 9, 10, 11, 12, 13 and 14.
The use of a polypeptide comprised of an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 2, 9, 10, 11, 12, 13 and 14 for the manufacture of a medicament for the treatment of hyperthyroidism.
Dependencies are inferred from the claim text.