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US 2002/0160515 A1Published application
Formation of polyampholytes in the presence of a polyion
AssigneeMirus Bio Corporation
InventorsJon A. Wolff, James E. Hagstrom, Vladimir G. Budker, Vladimir S. Trubetskoy
Life of this patent
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Abstract
A polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.
Claims16
1) A process for enhancing delivery of a polyion to a cell, comprising:
- forming a polyampholyte having a net charge, in the presence of a polyion;
- and, delivering the complex into a cell.
7) A complex for delivering a polyion to a cell, comprising:
- a polyion;
- and, a polyampholyte having a net charge.
13) A process for extravasation of a complex, comprising:
- forming a complex of polyion and polyampholyte having a net charge;
- and, inserting the complex into a vessel;
- delivering the complex to an extravascular space.
Dependencies are inferred from the claim text.