Drug-immobilized particles and a process of purifying proteins
OwnerHiroshi Handa, Haruma Kawaguchiinventors
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Abstract
The invention includes a microsphere comprising styrene-glycidyl methacrylate polymer, and methods for isolation, purification and identification of receptors to a specific compound possessing physiological activity. In addition, the invention provides proteins isolated and purified using the microspheres of the invention.
Claims18
A microsphere which is prepared by coupling a substance possessing physiological activity to a styrene-glycidyl methyacrylate polymer through a spacer, wherein at least one functional group of any of the substance possessing physiological activity, the polymer or spacer is converted to another type of functional group.
A microsphere comprising a substance possessing physiological activity, a polymer and a spacer, wherein at least one functional group of any of the substance possessing physiological activity, the polymer or spacer is converted to another type of functional group.
A process of preparing a microsphere comprising coupling a substance possessing physiological activity to a styrene-glycidyl methyacrylate polymer through a spacer, wherein at least one functional group of any of the substance possessing physiological activity, the polymer or spacer, is converted to another type of functional group.
A process of isolating a substance that can adhere to a substance possessing physiological activity from a mixture containing the substance, comprising contacting the mixture with a microsphere prepared by coupling the substance possessing physiological activity to a polymer through a spacer, and isolating the substance from the mixture, wherein the substance is selected from the group consisting of DM852, H-9, DQ2511 and KF49389 and derivatives thereof.
Dependencies are inferred from the claim text.