Novel gene encoding a sodium channel beta-3 subunit protein
AssigneeMillennium Pharmaceuticals, Inc., a Delaware corporation
InventorsRory A.J. Curtis, M. Alexandra Glucksmann
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AssigneeMillennium Pharmaceuticals, Inc., a Delaware corporation
InventorsRory A.J. Curtis, M. Alexandra Glucksmann
Estimating the term…
The invention provides an isolated nucleic acid molecule encoding a novel rat sodium channel protein β subunit. This nucleic acid molecules encodes a transmembrane protein that bears substantially sequence similarity to mammalian sodium channel protein subunits. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.
An isolated nucleic acid molecule selected from the group consisting of:
An isolated polypeptide selected from the group consisting of:
Dependencies are inferred from the claim text.