Expression of proteins in milk
OwnerHarry Meade, Nils Lonberginventors
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Abstract
This invention relates to the production of recombinant proteins in mammals' milk. Particularly, this invention relates to an expression system which when transgenically incorporated into a mammal permits the female species of that mammal to produce the desired recombinant protein in or along with its milk. This invention also relates to the transgenic mammal that produces the desired recombinant product in its milk.
Claims10
Mammals' milk comprising a recombinant protein, said protein being produced along with or in said milk by the mammals.
A process for the production of a recombinant protein comprising the steps of collecting milk from a transgenic mammal characterized by an expression system comprising a milk-specific promoter or a promoter specifically activated in mammary tissue operatively linked to a DNA sequence coding for the recombinant protein through a DNA sequence coding for a signal peptide effective in secreting and maturing the recombinant protein in mammary tissue and isolating the recombinant protein from the milk.
A DNA sequence comprising a milk-specific promoter or a promoter specifically activated in mammary tissue operatively linked to a DNA sequence coding for a recombinant protein through a DNA sequence coding for a signal peptide effective in secreting and maturing the recombinant protein in mammary tissue.
Dependencies are inferred from the claim text.