Method for coating medical device surfaces

A method of coating a hydrophilic polymer on a surface of a medical device, wherein;

• (a) the medical device has a quinone moiety disposed on the surface of said device;
• and
• (b) the hydrophilic polymer comprises a chemical moiety selected from the group consisting of an amine moiety, a sulfhydryl moiety and a hydroxyl moiety, wherein;
• the method comprises coating the medical device with the hydrophilic polymer to form a chemical bond between the chemical moiety of the hydrophilic polymer and the quinone moiety of the medical device surface.

A method of coating a hydrophilic polymer on a surface of a medical device, wherein;

• (a) the medical device has a quinone moiety disposed on the surface of said device;
• and
• (b) the hydrophilic polymer comprises a guanidino moiety, wherein;
• the method comprises coating the medical device with the hydrophilic polymer to form a chemical bond between the guanidino moiety of the hydrophilic polymer and the quinone moiety of the medical device surface.

A method of coating a hydrophilic polymer on a surface of a medical device, wherein;

• (a) the medical device has a semiquinone moiety disposed on the surface of said device;
• and
• (b) the hydrophilic polymer comprises a chemical moiety capable of forming a chemical bond with a semiquinone moiety, wherein;
• the method comprises coating the medical device with the hydrophilic polymer to form a chemical bond between the chemical moiety of the hydrophilic polymer and the semiquinone moiety of the medical device surface.

A method of coating a hydrophilic polymer on a surface of a medical device, wherein;

• (a) the medical device has a chemical moiety selected from the group consisting of a hydroxyl moiety, a phosphate moiety, a sulfate moiety, a carboxylate moiety, an amide moiety, a guanidino moiety and an amine moiety disposed on the surface of said device;
• and
• (b) the hydrophilic polymer comprises a catechol moiety, wherein;
• the method comprises coating the medical device with the hydrophilic polymer to form a chemical bond between the catechol moiety of the hydrophilic polymer and the chemical moiety of the medical device surface.

A method of coating a hydrophilic polymer on a surface of a medical device, wherein;

• (a) the medical device has a chemical moiety selected from the group consisting of an amine moiety, a sulfhydryl moiety and a hydroxyl moiety disposed on the surface of said device;
• and
• (b) the hydrophilic polymer comprises a quinone moiety, wherein;
• the method comprises coating the medical device with the hydrophilic polymer to form a chemical bond between the quinone moiety of the hydrophilic polymer and the chemical moiety of the medical device surface.

A method of coating a hydrophilic polymer on a surface of a medical device, wherein;

• (a) the medical device has a guanidino moiety disposed on the surface of said device;
• and
• (b) the hydrophilic polymer comprises a quinone moiety, wherein;
• the method comprises coating the medical device with the hydrophilic polymer to form a chemical bond between the quinone moiety of the hydrophilic polymer and the guanidino moiety of the medical device surface.

A method of coating a hydrophilic polymer on a surface of a medical device, wherein;

• (a) the medical device has a chemical moiety capable of forming a chemical bond with a semiquinone moiety disposed on the surface of said device;
• and
• (b) the hydrophilic polymer comprises a semiquinone moiety, wherein;
• the method comprises coating the medical device with the hydrophilic polymer to form a chemical bond between the semiquinone moiety of the hydrophilic polymer and the chemical moiety of the medical device surface.

A method of coating a biomolecule on a surface of a medical device, wherein;

• (a) the medical device has a hydrophilic polymer comprising a catechol moiety disposed on the surface of said device;
• and
• (b) the biomolecule comprises a chemical moiety selected from the group consisting of a hydroxyl moiety, a phosphate moiety, a sulfate moiety, a carboxylate moiety, an amide moiety, a guanidino moiety and an amine moiety, wherein;
• the method comprises coating the medical device with the biomolecule to form a chemical bond between the chemical moiety of the biomolecule and the catechol moiety of the hydrophilic polymer.

A method of coating a biomolecule on a surface of a medical device, wherein;

• (a) the medical device has a hydrophilic polymer comprising a quinone moiety disposed on the surface of said device;
• and
• (b) the biomolecule comprises a chemical moiety selected from the group consisting of an amine moiety, a sulfhydryl moiety and a hydroxyl moiety, wherein;
• the method comprises coating the medical device with the biomolecule to form a chemical bond between the chemical moiety of the biomolecule and the quinone moiety of the hydrophilic polymer.

A method of coating a biomolecule on a surface of a medical device, wherein;

• (a) the medical device has a hydrophilic polymer comprising a quinone moiety disposed on the surface of said device;
• and
• (b) the biomolecule comprises a guanidino moiety, wherein;
• the method comprises coating the medical device with the biomolecule to form a chemical bond between the guanidino moiety of the biomolecule and the quinone moiety of the hydrophilic polymer.

A method of coating a biomolecule on a surface of a medical device, wherein;

• (a) the medical device has a hydrophilic polymer comprising a semiquinone moiety disposed on the surface of said device;
• and
• (b) the biomolecule comprises a chemical moiety capable of forming a chemical bond with a semiquinone moiety, wherein;
• the method comprises coating the medical device with the biomolecule to form a chemical bond between the chemical moiety of the biomolecule and the semiquinone moiety of the hydrophilic polymer.

A method of coating a biomolecule on a surface of a medical device, wherein;

• (a) the medical device has a hydrophilic polymer comprising a chemical moiety selected from the group consisting of a hydroxyl moiety, a phosphate moiety, a sulfate moiety, a carboxylate moiety, an amide moiety, a guanidino moiety and an amine moiety disposed on the surface of said device;
• and
• (b) the biomolecule comprises a catechol moiety, wherein;
• the method comprises coating the medical device with the biomolecule to form a chemical bond between the catechol moiety of the biomolecule and the chemical moiety of the hydrophilic polymer.

A method of coating a biomolecule on a surface of a medical device, wherein;

• (a) the medical device has a hydrophilic polymer comprising a chemical moiety selected from the group consisting of an amine moiety, a sulfhydryl moiety and a hydroxyl moiety disposed on the surface of said device;
• and
• (b) the biomolecule comprises a quinone moiety, wherein;
• the method comprises coating the medical device with the biomolecule to form a chemical bond between the quinone moiety of the biomolecule and the chemical moiety of the hydrophilic polymer.

A method of coating a biomolecule on a surface of a medical device, wherein;

• (a) the medical device has a hydrophilic polymer comprising a guanidino moiety disposed on the surface of said device;
• and
• (b) the biomolecule comprises a quinone moiety, wherein;
• the method comprises coating the medical device with the biomolecule to form a chemical bond between the quinone moiety of the biomolecule and the guanidino moiety of the hydrophilic polymer.

A method of coating a biomolecule on a surface of a medical device, wherein;

• (a) the medical device has a hydrophilic polymer comprising a chemical moiety capable of forming a chemical bond with a semiquinone moiety disposed on the surface of said device;
• and
• (b) the biomolecule comprises a semiquinone moiety, wherein;
• the method comprises coating the medical device with the biomolecule to form a chemical bond between the semiquinone moiety of the biomolecule and the chemical moiety of the hydrophilic polymer.

A method of coating a hydrophilic polymer on a surface of a medical device, wherein;

• (a) the medical device has a metallic ion or a metal oxide disposed on the surface of said device;
• and
• (b) the hydrophilic polymer comprises a catechol moiety, wherein;
• the method comprises coating the medical device with the hydrophilic polymer to form a chemical bond between the catechol moiety of the hydrophilic polymer and the metallic ion or the metal oxide of the medical device surface.