Powder compositions
OwnerYuh-Fun Maa, Lu Zhao +1inventors
InventorsYuh-Fun Maa, Lu Zhao, Steven J. Prestrelski
Life of this patent
Estimating the term…
Abstract
A gel-forming free-flowing powder suitable for use as a vaccine is prepared by spray-drying or spray freeze-drying an aqueous suspension that contains an antigen adsorbed to an aluminum salt or calcium salt adjuvant, a saccharide, an amino acid or a salt thereof, and a colloidal substance. Powder for vaccine purposes are also prepared by spray freeze-drying an aqueous suspension of such an adjuvant having an antigen adsorbed therein. Processes for forming these powder compositions are also described, as well as methods of using the compositions in a vaccination procedure.
Claims49
A gel-forming free-flowing powder suitable for use as a vaccine, said powder being obtained by spray-drying or spray freeze-drying an aqueous suspension comprising:
- (a) from 0.1 to 0.95% by weight of an aluminum salt or calcium salt adjuvant having an antigen adsorbed therein;
- (b) from 0.5 to 6% by weight of a saccharide;
- (c) from 0.1 to 2% by weight of an amino acid or salt thereof;
- and
- (d) from 0.02 to 1% by weight of a colloidal substance.
A process for the preparation of a gel-forming free-flowing powder suitable for use as a vaccine, which process comprises the step of spray-drying or spray freeze-drying an aqueous suspension comprising:
- (a) from 0.1 to 0.95% by weight of an aluminum salt or calcium salt adjuvant having an antigen adsorbed therein;
- (b) from 0.5 to 6% by weight of a saccharide;
- (c) from 0.1 to 2% by weight of an amino acid or salt thereof;
- and
- (d) from 0.02 to 1% by weight of a colloidal substance.
A dosage receptacle for a needleless syringe, said receptacle containing an effective amount of a gel-forming free-flowing powder obtained by spray-drying or spray freeze-drying an aqueous suspension comprising:
- (a) from 0.1 to 0.95% by weight of an aluminum salt or calcium salt adjuvant having an antigen adsorbed therein;
- (b) from 0.5 to 6% by weight of a saccharide;
- (c) from 0.1 to 2% by weight of an amino acid or salt thereof;
- and
- (d) from 0.02 to 1% by weight of a colloidal substance.
A needleless syringe which is loaded with a gel-forming free-flowing powder obtained by spray-drying or spray freeze-drying an aqueous suspension comprising:
- (a) from 0.1 to 0.95% by weight of an aluminum salt or calcium salt adjuvant having an antigen adsorbed therein;
- (b) from 0.5 to 6% by weight of a saccharide;
- (c) from 0.1 to 2% by weight of an amino acid or salt thereof;
- and
- (d) from 0.02 to 1% by weight of a colloidal substance.
A vaccine composition comprising a pharmaceutically acceptable carrier or diluent and a gel-forming free-flowing powder obtained by spray-drying or spray freeze-drying an aqueous suspension comprising:
- (a) from 0.1 to 0.95% by weight of an aluminum salt or calcium salt adjuvant having an antigen adsorbed therein;
- (b) from 0.5 to 6% by weight of a saccharide;
- (c) from 0.1 to 2% by weight of an amino acid or salt thereof;
- and
- (d) from 0.02 to 1% by weight of a colloidal substance.
A method of vaccinating a subject, which method comprises the step of administering to the said subject an effective amount of a gel-forming free-flowing powder obtained by spray-drying or spray freeze-drying an aqueous suspension comprising:
- (a) from 0.1 to 0.95% by weight of an aluminum salt or calcium salt adjuvant having an antigen adsorbed therein;
- (b) from 0.5 to 6% by weight of a saccharide;
- (c) from 0.1 to 2% by weight of an amino acid or salt thereof;
- and
- (d) from 0.02 to 1% by weight of a colloidal substance.
A gel-forming free-flowing powder suitable for use as a vaccine, which powder comprises:
- (i) from 5 to 60% by weight of an aluminum salt or calcium salt adjuvant having an antigen adsorbed thereon;
- (ii) from 25 to 90% by weight of a saccharide;
- (iii) from 4.5 to 40% by weight of an amino acid or salt thereof;
- and
- (iv) from 0.5 to 10% by weight of a colloidal substance.
A powder suitable for use as a vaccine, said powder being obtained by spray freeze-drying an aqueous suspension comprising an aluminum salt or calcium salt adjuvant having an antigen adsorbed therein.
A process for the preparation of a powder suitable for use as a vaccine, which process comprises the step of spray freeze-drying an aqueous suspension comprising an aluminum salt or calcium salt adjuvant having an antigen adsorbed therein.
A dosage receptacle for a needleless syringe, said receptacle containing an effective amount of a powder obtained by spray freeze-drying an aqueous suspension comprising an aluminum salt or calcium salt adjuvant having an antigen adsorbed therein.
A needleless syringe which is loaded with a powder obtained by spray freeze-drying an aqueous suspension comprising an aluminum salt or calcium salt adjuvant having an antigen adsorbed therein.
A vaccine composition comprising a pharmaceutically acceptable carrier or diluent and a powder obtained by spray freeze-drying an aqueous suspension comprising an aluminum salt or calcium salt adjuvant having an antigen adsorbed therein.
A method of vaccinating a subject, which method comprises administering to the said subject an effective amount of a powder obtained by spray freeze-drying an aqueous suspension comprising an aluminum salt or calcium salt adjuvant having an antigen adsorbed therein.
Dependencies are inferred from the claim text.