Bridged piperazine derivatives

A compound of the formula

• 84
• or the pharmaceutically acceptable salt and pro-drugs thereof;
• wherein a is 1, 2, 3, 4 or 5;
• c is 0 or 1;
• d is 1,2,3,4or 5;
• k is 0, 1, 2, 3 or 4;
• l is 0, 1, 2, 3 or 4;
• m is 0, 1, 2, 3, or 4;
• k, l and m cannot all be 0 and if m and/or k are not 0, then I must be 0.;
• W is CH or N;
• X is C(O), C(S) or CH2;
• Y is CH2;
• Z is oxygen, NR9 or CR11R12;
• each R1 is independently selected from hydrogen, hydroxy, hydroxysulfonyl, halo, (C1-C6)alkyl, mercapto, mercapto(C1-C6)alkyl, (C1-C6)alkylthio, (C1-C6)alkylsulfinyl, (C1-C6)alkylsufonyl, (C1-C6)alkylthio(C1-C6)alkyl, (C1-C6)alkylsulfinyl(C1-C6)alkyl, (C1-C6)alkylsulfonyl(C1-C6)alkyl, (C1-C6)alkoxy, (C6-C10)aryloxy, halo(C1-C6)alkyl, trifluoromethyl, formyl, formyl(C1-C6)alkyl, nitro, nitroso, cyano, (C6-C10)aryl(C1-C6)alkoxy, halo(C1-C6)alkoxy, trifluoromethoxy, (C3-C7)cycloalkyl, (C3-C7)cycloalkyl(C1-C6)alkyl, hydroxy(C3-C7)cycloalkyl(C1-C6)alkyl, (C3-C7)cycloalkylamino, (C3-C7)cycloalkylamino(C1-C6)alkyl, ((C3-C7)cycloalkyl)((C1-C6)alkyl)amino, ((C3-C7)cycloalkyl(C1-C6)alkyl)amino(C1-C6)alkyl, cyano(C1-C6)alkyl, (C2-C7)alkenyl, (C2-C7)alkynyl, (C6-C10)aryl, (C6-C10)aryl(C-C6)alkyl, (C6-C10)aryl(C2-C6)alkenyl, hydroxy(C1-C6)alkyl, hydroxy(C6-C10)aryl (C1-C6)alkyl, hydroxy(C1-C6)alkylthio(C1-C6)alkyl, hydroxy(C2-C6)alkenyl, hydroxy(C2-C6)alkynyl, (C1-C6)alkoxy(C1-C6)alkyl, (C1-C6)alkoxy(C6-C10)aryl(C1-C6)alkyl, (C6-C10)aryloxy(C1-C6)alkyl, (C6-C10)aryl(C1-C6)alkoxy(C1-C6)alkyl, amino, (C1-C6)alkylamino, ((C1-C6)alkyl)2amino, (C6-C10)arylamino, (C6-C10)aryl(C1-C6)alkylamino, amino(C1-C6)alkyl, (C1-C6)alkylamino(C1-C6)alkyl, ((C1-C6)alkyl)2amino(C1-C6)alkyl, hydroxy(C1-C6)alkylamino(C1-C6)alkyl, (C6-C10)arylamino(C1-C6)alkyl, (C6-C10)aryl (C1-C6)alkylamino(C1-C6)alkyl, (C1-C6)alkylcarbonylamino, ((C1-C6)alkylcarbonyl)((C1-C6)alkyl)amino, (C1-C6)alkylcarbonylamino(C1-C6)alkyl, ((C1-C6)alkylcarbonyl)((C1-C6)alkyl)amino(C1-C6)alkyl, (C1-C6)alkoxycarbonylamino, (C1-C6)alkoxycarbonyl)(C1-C6)alkylamino, (C1-C6)alkoxycarbonylamino(C1-C6)alkyl, (C1-C6)alkoxycarbnony)((C1-C6)alkyl)amino(C1-C6)alkyl, carboxy, (C1-C6)alkoxycarbonyl, (C6-C10)aryl(C1-C6)alkoxycarbonyl, (C1-C6)alkylcarbonyl, (C1-C6)alkylcarbonyl(C1-C6)alkyl, (C6-C10)arylcarbonyl, (C6-C10)arylcarbonyl(C1-C6)alkyl, (C6-C10)aryl(C1-C6)alkylcarbonyl, (C6-C10)aryl(C1-C6)alkycarbonyl(C1-C6)alkyl, carboxy(C1-C6)alkyl, (C1-C6)alkoxycarbonyl(C1-C6)alkyl, (C6-C10)aryl(C1-C6)alkoxycarbonyl(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkylcarbonyloxy(C1-C6)alkyl, aminocarbonyl, (C1-C6)alkylaminocarbonyl, ((C1-C6)alkyl)2aminocarbonyl, (C6-C10)arylaminocarbonyl, (C6-C10)aryl(C1-C6)alkylaminocarbonyl, aminocarbonyl(C1-C6)alkyl, (C1-C6)alkylaminocarbonyl(C1-C6)alkyl, ((C1-C6)alkyl)2aminocarbonyl(C1-C6)alkyl, (C6-C10)arylaminocarbonyl(C1-C6)alkyl, (C1-C6)alkylaminocarbonyl(C1-C6)alkyl, amidino, guanidino, ureido, (C1-C6)alkylureido, ((C1-C6)alkyl)2ureido, ureido(C1-C6)alkyl, (C1-C6)alkylureido(C1-C6)alkyl, ((C1-C6)alkyl)2ureido(C1-C6)alkyl, (C2-C9)heterocycloalkyl, (C2-C9)heteroaryl, (C2-C9)heterocycloalkyl(C1-C6)alkyl and (C2-C9)heteroaryl(C1-C6)alkyl;
• R4 is (R5Qq)f(C6-C10)aryl, (R5Qq)f(C3-C10)cycloalkyl, (R5Qq)KC2-C9)heteroaryl, (R5Qq)KC2-C9)heterocycloalkyl,
• wherein f is 0, 1,2,3,4 or 5;
• Q is (C1-C6)alkyl;
• q is 0 or 1;
• R5 is independently selected from:
• (C2-C9)heterocycloalkylcarbonyl, (C2-C9)heteroarylcarbonyl, (C2-C9)heteroaryl(C1-C6)alkylaminocarbonyl, (C2-C9)heteroarylaminocarbonyl, (C2-C9)heterocycloalkyl(C1-C6)alkylaminocarbonyl, (C1-C6)alkylsulfonylaminocarbonyl, (C1-C6)alkylsulfonylamino(C1-C6)alkylaminocarbonyl, ureido(C1-C6)alkylaminocarbonyl, (C1-C6)alkylureido(C1-C6)alkylaminocarbonyl, ((C1-C6)alkyl)2ureido(C1-C6)alkylaminocarbonyl, halo(C1-C6)alkylaminocarbonyl, (C1-C6)alkylcarbonylamino(C1-C6)alkylaminocarbonyl, hydroxy(C1-C6)alkylaminocarbonyl, aminosulfonyl(C1-C6)alkylaminocarbonyl, carboxy(C1-C6)alkylaminocarbonyl, (C1-C6)alkylaminosulfonyl(C1-C6)alkylaminocarbonyl, amino(C1-C6)alkylcarbonylamino, (C1-C6)alkylamino(C1-C6)alkylcarbonylamino, carboxy(C1-C6)alkylcarbonylamino, carboxy(C1-C6)alkoxycarbonylamino, ((C1-C6)alkyl)2amino(C1-C6)alkylcarbonylamino, acetylamino(C1-*C6)alkylcarbonylamino, (acetyl)((C1-C6)alkyl)amino(C1-C6)alkylcarbonylamino, (C1-C6)alkylsulfonylamino(C1-C6)alkylcarbonylamino, cyanoguanidino(C1-C6)alkylcarbonylamino, (C1-C6)alkylcyanoguanidino(C1-C6)alkylcarbonylamino, ((C1-C6)alkyl)2cyanoguanidino(C1-C6)alkylcarbonylamino, aminocarbonyl(C1-C6)alkylcarbonylamino, aminocarbonylamino(C1-C6)alkylcarbonylamino, (C1-C6)alkylaminocarbonylamino(C1-C6)alkylcarbonylamino, ((C1-C6)alkyl)2aminocarbonylamino(C1-C6)alkylcarbonylamino, (C2-C9)heteroaryl(C1-C6)alkylcarbonylamino, (C2-C9)heterocycloalkyl(C1-C6)alkylcarbonylamino, aminosulfonyl(C1-C6)alkylcarbonylamino, hydroxy(C1-C6)alkylureido, amino(C1-C6)alkylureido, (C1-C6)alkylamino(C1-C6)alkylureido, ((C1-C6)alkyl)2amino(C1-C6)alkylureido, (C2-C9)heterocycloalkyl (C1-C6)alkylureido, (C2-C9)heteroarylureido, (C2-C9)heteroaryl(C1-C6)alkylureido, (C1-C6)alkylsulfonylureido, aminosulfonyl(C1-C6)alkylureido, aminocarbonyl(C1-C6)alkylureido, (C1-C6)alkylaminocarbonyl(C1-C6)alkylureido, ((C1-C6)alkyl)2aminocarbonyl(C1-C6)alkylureido, acetylamino(C1-C6)alkylureido, (acetyl)((C1-C6)alkyl)amino(C1-C6)alkylureido, carboxy(C1-C6)alkylureido, halo(C1-C6)alkylsulfonylamino, amino(C1-C6)alkylsulfonylamino, (C1-C6)alkylamino(C1-C6)alkylsulfonylamino, ((C1-C6)alkyl)2amino(C1-C6)alkylsulfonylamino, acetylamino(C1-C6)alkylsulfonylamino, (acetyl)((C1-C6)alkyl)amino(C1-C6)alkylsulfonylamino, ureido(C1-C6)alkylsulfonylamino, (C1-C6)alkylureido(C1-C6)alkylsulfonylamino, ((C1-C6)alkyl)2ureido(C1-C6)alkylsulfonylamino, (C1-C6)alkylsulfonylamino(C1-C6)alkylsulfonylamino, cyanoguanidino(C1-C6)alkylsulfonylamino, carboxy(C1-C6)alkylsulfonylamino, (C1-C6)alkylcyanoguanidino(C1-C6)alkylsulfonylamino, ((C1-C6)alkyl)2cyanoguanidino(C1-C6)alkylsulfonylamino, aminocarbonyl(C1-C6)alkylsulfonylamino, (C1-C6)alkoxycarbonylamino(C1-C6)alkylsulfonylamino, aminosulfonylaminocarbonyl(C1-C6)alkylaminosuffonylaminocarbonyl, ((C1-C6)alkyl)2aminosulfonylaminocarbonyl, (C6-C10)arylsulfonyl, (C1-C6)alkylaminosulfonylamino, ((C1-C6)alkyl)2aminosulfonylamino, aminocarbonyl(C1-C6)alkylamino(C1-C6)alkylsulfonylamino, (C2-C9)heterocycloalkyloxycarbonylamino(C1-C6)alkylsulfonylamino, (C2-C9)heteroaryloxycarbonylamino(C1-C6)alkylsulfonylamino, cyanoguanidino, (C1-C6)alkylcyanoguanidino, ((C1-C6)alkyl)2cyanoguanidino, (C2-C9)heterocycloalkylcyanoguanidino, (C2-C9)heterocycloalkyl (C1-C6)alkylcyanoguanidino, (C2-C9)heteroaryl(C1-C6)alkylcyanoguanidino, amino(C1-C6)alkylcyanoguanidino, (C1-C6)alkylamino(C1-C6)alkylcyanoguanidino, ((C1-C6)alkyl)2amino(C1-C6)alkylcyanoguanidino, aminocarbonyl(C1-C6)alkylcyanoguanidino, carboxy(C1-C6)alkylcyanoguanidino;
• (C1-C6)alkylaminocarbonyl(C1-C6)alkylcyanoguanidino, ((C1-C6)alkyl)2aminocarbonyl(C1-C6)alkylcyanoguanidino, hydroxy(C1-C6)alkylamino, aminocarbonyl(C1-C6)alkylamino, carboxy(C1-C6)alkylamino, (C1-C6)alkylsulfonylamino(C1-C6)alkylamino, (C1-C6)alkoxycarbonylamino(C1-C6)alkylamino, aminosulfonyl(C1-C6)alkylamino, (C2-C9)heteroaryl(C1-C6)alkylamino, acetylamino(C1-C6)alkylamino, (acetyl)((C1-C6)alkyl)amino(C1-C6)alkylamino, (C2-C9)heterocycloalkyl (C1-C6)alkylamino, ((C1-C6)alkyl)2amino(C1-C6)alkylamino, (C1-C6)alkylamino(C1-C6)alkylamino,(C1-C6)alkoxy(C1-C6)alkylamino, (C1-C6)alkoxycarbonyl(C1-C6)alkylamino, cyano(C1-C6)alkylamino, (C2-C9)heterocycloalkyloxycarbonylamino(C1-C6)alkylamino, (C2-C9)heteroaryloxycarbonylamino(C1-C6)alkylamino, cyanoguanidino(C1-C6)alkylamino, (C1-C6)alkylcyanoguanidino(C1-C6)alkylamino, ((C1-C6)alkyl)2cyanoguanidino(C1-C6)alkylamino, ureido(C1-C6)alkylamino, (C1-C6)alkylureido(C1-C6)alkylamino, ((C1-C6)alkyl)2ureido(C1-C6)alkylamino, aminocarbonyloxy(C1-C6)alkylamino, hydroxy(C1-C6)alkylcarbonylamino, (C1-C6)alkylaminocarbonyl(C1-C6)alkylcarbonylamino, ((C1-C6)alkyl)2aminocarbonyl(C1-C6)alkylcarbonylamino, (C1-C6)alkoxycarbonylamino(C1-C6)alkylcarbonylamino, aminosulfonyl(C1-C6)alkylcarbonylamino, hydroxy(C1-C6)alkylamino(C1-C6)alkylcarbonylamino, ((C1-C6)alkyl)2amino(C1-C6)alkylamino(C1-C6)alkylcarbonylamino (C1-C6)alkylamino(C1-C6)alkylamino(C1-C6)alkylcarbonylamino, amino(C1-C6)alkylamino(C1-C6)alkylcarbonylamino, (C1-C6)alkoxy(C1-C6)alkylamino(C1-C6)alkylcarbonylamino, (C2-C9)heterocycloalkyloxycarbonylamino, (C2-C9)heteroarylcarbonylamino(C1-C6)alkylcarbonylamino, (C2-C9)heteroarylcarbonylamino, (C2-C9)heterocycloalkylcarbonylamino, (C2-C9)heteroaryl(C1-C6)alkylcarbonylamino, (C2-C9)heterocycloalkyl(C1-C6)alkylcarbonylamino, (C2-C9)heterocycloalkylcarbonylamino(C1-C6)alkylcarbonylamino, cyano(C1-C6)alkylcarbonylamino, (C1-C6)alkylsulfonylamino(C1-C6)alkylaminocarbonylamino, (C1-C6)alkoxycarbonylamino(C1-C6)alkylaminocarbonylamino, (C2-C9)heterocycloalkyloxycarbonylamino(C1-C6)alkylaminocarbonylamino, (C2-C9)heteroaryloxycarbonylamino(C1-C6)alkylaminocarbonylaminol, ureido(C1-C6)alkylureido, (C1-C6)alkylureido(C1-C6)alkylureido, ((C1-C6)alkyl)2ureido(C1-C6)alkylureido, cyanoguanidino(C1-C6)alkylureido, (C2-C9)heteroaryl(cyanoguanidino), aminosulfonyl, amino(C1-C6)alkylsulfonyl, (C1-C6)alkylamino(C1-C6)alkylsulfonyl, ((C1-C6)alkyl)2amino(C1-C6)alkylsulfonyl, (C1-C6)alkylaminosulfonyl, ((C1-C6)alkyl)2aminosulfonyl, (C2-C9)heterocycloalkylsulfonyl, amino(C1-C6)alkylaminosulfonyl, (C1-C6)alkylamino(C1-C6)alkylaminosulfonyl, ((C1-C6)alkyl)2amino(C1-C6)alkylaminosulfonyl, (C2C9)heteroarylaminosulfonyl, hydroxy(C1-C6)alkylaminosulfonyl, (C1-C6)alkoxy(C1-C6)alkylaminosulfonyl, ureido(C1-C6)alkylaminosulfonyl, (C1-C6)alkylureido(C1-C6)alkylaminosulfonyl, ((C1-C6)alkyl)2ureido(C1-C6)alkylaminosulfonyl, (C1-C6)alkylsulfonylamino(C1-C6)alkylaminosulfonyl, (C1-C6)alkoxycarbonylamino(C1-C6)alkylaminosulfonyl, (C2-C9)heterocycloalkyloxycarbonylamino(C1-C6)alkylaminosulfonyl, (C2-C9)heteroaryloxycarbonylamino(C1-C6)alkylaminosulfonyl, aminocarbonyl(C1-C6)alkylaminosulfonyl, cyanoguanidino(C1-C6)alkylaminosulfonyl, (C2-C9)heteroarylaminosulfonyl, (C2-C9)heteroaryl (C1-C6)alkylaminosulfonyl, (C2-C9)heterocycloalkylaminosulfonyl, (C1-C6)alkylcarbonylaminosulfonyl, halo(C1-C6)alkylcarbonylaminosulfonyl, (C1-C6)alkoxycarbonylaminosulfonyl, ureidosulfonyl, (C1-C6)alkylureidosulfonyl, ((C1-C6)alkyl)2ureidosulfonyl, hydrogen, hydroxy, hydroxysulfonyl, halo, mercapto, (C1-C6)alkylthio, (C1-C6)alkylsulfinyl, (C1-C6)alkylsulfonyl, carboxy(C1-C6)alkylsulfonyl, (C6-C10)arylsulfonyl, (C2-C9)heteroarylsulfonyl, (C1-C6)alkoxy, hydroxy(C1-C6)alkoxy, (C6-C10)aryloxy, trifluoro(C1-C6)alkyl, formyl, nitro, nitroso, cyano halo(C1-C6)alkoxy, trifluoro(C1-C6)alkoxy, amino(C1-C6)alkoxy, (C3-C10)cycloalkylhydroxy(C3-C10)cycloalkyl (C3-C10)cycloalkylamino(C2-C6)alkenyl, (C2-C6)alkynyl, (C6-C10)aryl, (C6-C10)aryl(C2-C6)alkenyl, hydroxy(C6-C10)aryl, ((C1-C6)alkylamino)(C6-C10)aryl, hydroxy(C1-C6)alkylthio, hydroxy(C2-C6)alkenyl, hydroxy(C2-C6)alkynyl, (C1-C6)alkoxy(C6-C10)aryl, (C6-C10)aryl(C1-C6)alkoxy, amino, (C1-C6)alkylamino, ((C1-C6)alkyl)2amino, (C6-C10)arylamino, (C6-C10)aryl(C1-C6)alkylamino, amino(C1-C6)alkylamino, (C2-C9)heterocycloalkylamino, (C2-C9)heteroarylamino, (C2-C9)heteroaryl(C1-C6)alkylamino, , (C2-C9)heterocycloalkyl(C1-C6)alkylamino, (C3-C10)cycloalkyl(C1-C6)alkyl)amino, (C1-C6)alkylcarbonylamino, (C1-C6)alkoxycarbonylamino, (C2-C6)alkenylcarbonylamino, (C3-C10)cycloalkylcarbonylamino, (C6-C10)arylcarbonylamino, (C2-C9)heterocycloalkylcarbonylamino, (C2-C9)heteroaryloxycarbonylamino, (C2-C9)heterocycloalkoxycarbonylamino, halo(C1-C6)alkylcarbonylamino, (C1-C6)alkoxy(C1-C6)alkylcarbonylamino, (C1-C6)alkoxycarbonyl(C1-C6)alkylcarbonylamino, ((C1-C6)alkylcarbonyl)((C1-C6)alkyl)amino, ((C1-C6)alkoxycarbonyl)((C1-C6)alkyl)amino, (C1-C6)alkylsulfonylamino, ((C1-C6)alkylcarbonyl)((C1-C6)alkyl)amino, (C3-C1o)cycloalkyl(C1-C6)alkyl)amino, ((C1-C6)alkylsulfonyl)((C1-C6)alkyl)amino, (C2-C9)heteroarylsulfonylamino, (C6-C10)arylsulfonylamino, ((C6-C10)arylsulfonyl)((C1-C6)alkyl)amino, carboxy, (C1-C6)alkoxycarbonyl, (C6-C10)aryl(C1-C6)alkoxycarbonyl, (C1-C6)alkylcarbonyl, carboxy(C1-C6)alkylcarbonyl, amino(C1-C6)alkylcarbonyl, (C1-C6)alkylamino(C1-C6)alkylcarbonyl, ((C1-C6)alkyl)2amino(C1-C6)alkylcarbonyl, (C6-C10)arylcarbonyl, (C2-C9)heteroaryl(C1-C6)alkylcarbonyl, (C6-C10)aryl(C1-C6)alkylcarbonyl, hydroxy(C1-C6)alkoxycarbonyl, (C1-C6)alkoxy(C1-C6)alkylcarbonyloxy, ((C1-C6)alkyl)2aminocarbonyloxyaminocarbonyl, hydroxyaminocarbonyl, (C1-C6)alkylaminocarbonyl, ((C1-C6)alkyl)2aminocarbonyl, (C6-C10)arylaminocarbonyl, (C6-C10)aryl(C1-C6)alkylaminocarbonyl, (aminocarbonyl(C1-C6)alkylaminocarbonyl, ((C1-C6)alkylaminocarbonyl(C1-C6)alkylaminocarbonyl, (carboxy(C1-C6)alkyl)aminocarbonyl, ((C1-C6)alkoxycarbonyl(C1-C6)alkylaminocarbonyl, (amino(C1-C6)alkyl)aminocarbonyl, (hydroxy(C1-C6)alkylaminocarbonylamidino, hydroxyamidino, guanidino, ureido, (C1-C6)alkylureido, (C6-C10)arylureido, ((C6-C10)aryl)2ureido, (C6-C10)aryl(C1-C6)alkylureido, halo(C1-C6)alkylureido, ((C1-C6)alkyl)((C6-C10)aryl)ureido, ((C1-C6)alkyl)2ureido, halo(C1-C6)alkylcarbonylureido, (halo(C1-C6)alkyl)((C1-C6)alkyl)ureido, ((C1-C6)alkoxycarbonyl(C1-C6)alkyl)ureido, glycinamido, (C1-C6)alkylglycinamido, aminocarbonylglycinamido, (C1-C6)alkoxy(C1-C6)alkylcarbonylglycinamido, (aminocarbonyl)((C1-C6)alkyl)glycinamido, ((C1-C6)alkoxycarbonyl(C1-C6)alkylcarbonyl)((C1-C6)alkyl)glycinamido, ((C1-C6)alkoxycarbonylamino(C1-C6)alkylcarbonyl)glycinamido, (C6-C10)arylcarbonylglycinamido, ((C6-C10)arylcarbonyl)((C1-C6)alkyl)glycinamido, ((C6-C10)aryl(C1-C6)alkylaminocarbonyl)glycinamido, (C6-C10)aryl(C1-C6)alkylaminocarbonyl)((C1-C6)alkyl)glycinamido, (C6-C10)arylaminocarbonylglycinamido, ((C6-C10)arylaminocarbonyl)((C1-C6)alkyl)glycinamido, alaninamido, (C1-C6)alkylalaninamido, (C2-C9)heteroaryl, amino(C2-C9)heteroaryl, (C1-C6)alkylamino(C2-C9)heteroaryl, ((C1-C6)alkyl)2amino(C2-C9)heteroaryl, (C2-C9)heteroaryloxy, (C2-C9)heterocycloalkyl, carboxy(C1-C6)alkoxy, (C1-C6)alkylsulfonylaminocarbonyl(C1-C6)alkoxy, (C1-C6)alkylsulfonylamino(C1-C6)alkoxy, (C2-C9)heteroaryl(C1-C6)alkoxy, carboxy(C1-C6)alkylamino(C2-C6)alkoxy, amino(C2-C6)alkoxy, (aminocarbonyl)(hydroxy)amino, (C1-C6)alkylamino(C2-C6)alkoxy, ((C1-C6)alkyl)2amino(C2-C6)alkoxy, (C1-C6)alkylcarbonylamino(C2-C6)alkoxy, aminocarbonylamino(C2-C6)alkoxy, (C1-C6)alkylaminocarbonylamino(C2-C6)alkoxy, ((C1-C6)alkyl)2aminocarbonylamino(C2-C6)alkoxy, amino(C2-C6)alkoxycarbonylamino, (C1-C6)alkylamino(C2-C6)alkoxycarbonylamino, ((C1-C6)alkyl)2amino(C2-C6)alkoxycarbonylamino, C2-C9)heteroarylamino(C2-C6)alkoxy, barbituryl, (C1-C6)alkylcarbonylamino(C1-C6)alkylaminocarbonyl, amino(C1-C6)alkylcarbonylamino where the (C1-C6)alkyl is optionally substituted with one or two groups selected from hydrogen, amino, hydroxyl, (C1-C6)alkoxy, carboxy, further substituted (C2-C9)heteroaryl, (C6-C10)aryl, (C2-C9)heterocycloalkyl, and cycloalkyl, or the two groups together make up a carbocycle;
• and R19carbonylamino where R19 is a nitrogen containing (C2-C9)heterocycloalkyl which is optionally substituted further with one or two groups selected from (C1-C6)alkyl, (C2-C6)alkoxy and hydroxy;
• R9 is selected from the group consisting of hydrogen, (C1-C6)alkyl, (C6-C10)aryl, (C6-C10)aryl(C1-C6)alkyl, (C1-C6)alkylcarbonyl, (C1-C6)alkylcarbonyl(C1-C6)alkyl, (C6-C10)aryl(C1-C6)alkylcarbonyl, (C6-C10)aryl(C1-C6)alkylcarbonyl(C1-C6)alkyl, aminocarbonyl, (C1-*C6)alkylaminocarbonyl, ((C1-C6)alkyl)2aminocarbonyl and (C1-C6)alkoxycarbonyl;
• and
• R11 and R12 are each independently selected from the group consisting of hydrogen, (C1-C6)alkyl, (C6-C10)aryl, (C6-C10)aryl(C1-C6)alkyl, hydroxy, (C1-C6)alkoxy, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkyl, amino, (C1-C6)alkylamino, ((C1-C6)alkyl)2amino, (C1-C6)alkylcarbonylamino, (C3-CS)cycloalkylcarbonylamino, (C3-C8)cycloalkyl(C1-C6)alkylcarbonylamino, (C1-C6)alkoxycarbonylamino, (C1-C6)alkylsulfonylamino, (C6-C10)arylcarbonylamino, (C1-C6)alkoxycarbonyl(C1-C6)alkylcarbonylamino, (C6-C10)aryl(C1-C6)alkylcarbonylamino, ((C6-C10)aryl(C1-C6)alkylcarbonyl)((C1-C6)alkyl)amino, (C1-C6)alkylcarbonylamino(C1-C6)alkyl, (C3-C8)cycloalkylcarbonylamino(C1-C6)alkyl, (C1-C6)alkoxycarbonylamino(C1-C6)alkyl, (C2-C9)heterocycloalkylcarbonylamino(C1-C6)alkyl, (C6-C10)aryl (C1-C6)alkylcarbonylamino(C1-C6)alkyl, (C2-C9)heteroarylcarbonylamino(C1-C6)alkyl, (C6-C10)arylsulfonylamino, (C1-C6)alkylsulfonylamino(C1-C6)alkyl, aminocarbonylamino, (C1-C6)alkylaminocarbonylamino, halo(C1-C6)alkylaminocarbonylamino, ((C1-C6)alkyl)2aminocarbonylamino, aminocarbonylamino(C1-C6)alkyl, (C1-C6)alkylaminocarbonylamino(C1-C6)alkyl, ((C1-C6)alkyl)2aminocarbonylamino(C1-C6)alkyl, halo(C1-C6)alkylaminocarbonylamino(C1-C6)alkyl, amino(C1-C6)alkyl, (C1-C6)alkylamino(C1-C6)alkyl, ((C1-C6)alkyl)2amino(C1-C6)alkyl, carboxy(C1-C6)alkyl, (C1-C6)alkoxycarbonyl(C1-C6)alkyl, aminocarbonyl(C1-C6)alkyl and (C1-C6)alkylaminocarbonyl(C1-C6)alkyl.