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US 2002/0119553 A1Published application
Human secreted protein, ZZP1
AssigneeZymoGenetics, Inc.
InventorsEdward C. Thayer, Philippa J. Webster
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Abstract
The present invention relates to polynucleotide and polypeptide molecules, and variants thereof, for Zzp1, a novel Zona Pellucida protein. The polypeptides, and polynucleotides encoding them, are fertility modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the Zzp1 polypeptides.
Claims22
An isolated polypeptide molecule comprising residues 26 to 546 of SEQ ID NO:2.
A method of producing an antibody to a polypeptide comprising the following steps:
- inoculating an animal with the polypeptide such that the polypeptide elicits an immune response in the animal to produce the antibody;
- and
- isolating the antibody from the animal,
- wherein the polypeptide is chosen from,
- a) a polypeptide comprising residues 26 to 546 of SEQ ID NO:2;.
- b) a polypeptide comprising residues 26 to 627 of SEQ ID NO:2;
- and
- c) a polypeptide comprising residues 1 to 627 of SEQ ID NO:2
- and wherein the antibody produced by the method specifically binds to a polypeptide of SEQ ID NO:2.
6 more elements
A method of producing an antibody to a polypeptide comprising the following steps:
- inoculating an animal with the polypeptide such that the polypeptide elicits an immune response in the animal to produce the antibody;
- and
- isolating the antibody from the animal,
- wherein the polypeptide comprises at least fifteen consecutive amino acids of the amino acid sequence as shown in SEQ ID NO:2,
- and wherein the antibody produced by the method specifically binds to a polypeptide of SEQ ID NO:2.
2 more elements
Dependencies are inferred from the claim text.