Diagnosis and treatment of PTP04 related disorders
AssigneeSugen, Inc.
InventorsBahija Jallal, Gregory D. Plowman
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Abstract
The present invention relates to PTP04 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animal containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis, and screening are provided for PTP04 related diseases or conditions characterized by an abnormal interaction between a PTP04 binding partner.
Claims22
An isolated, enriched or purified nucleic acid molecule encoding a PTP04 polypeptide.
A nucleic acid probe for the detection of nucleic acid encoding a PTP04 polypeptide in a sample.
A nucleic acid molecule comprising one or more regions that encode a PTP04 polypeptide or a PTP04 domain polypeptide, wherein said PTP04 polypeptide or said PTP04 domain polypeptide is fused to a non-PTP04 polypeptide.
A recombinant cell comprising a nucleic acid molecule encoding either
- (a) a PTP04 polypeptide;
- (b) a PTP04 domain polypeptide;
- or
- (c) a PTP04 polypeptide or PTP04 domain polypeptide fused to a non-PTP04 polypeptide.
An isolated, enriched or purified PTP04 polypeptide.
An antibody or antibody fragment having specific binding affinity to a PTP04 polypeptide or a PTP04 domain polypeptide.
A hybridoma which produces an antibody having specific binding affinity to a PTP04 polypeptide.
A method for identifying a substance capable of modulating PTP04 activity comprising the steps of:
- (a) contacting a PTP04 polypeptide with a test substance, and
- (b) determining whether said substance alters the activity of said polypeptide.
A method for identifying a substance capable of modulating PTP04 activity in a cell comprising the steps of:
- (a) expressing a PTP04 polypeptide in a cell,
- (b) adding a test substance to said cells, and
- (c) monitoring a change in cell phenotype, cell proliferation, cell differentiation, PTP04 catalytic activity, or the interaction between a PTP04 polypeptide and a natural binding partner.
A method of preventing or treating an abnormal condition by administering to a patient in need of such treatment a compound that modulates the function of a PTP04 polypeptide.
Dependencies are inferred from the claim text.