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AssigneeThe United States of America as represented by the Department of Veterans Affairs
InventorHugo R. Rosen
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The present invention provides a method of identifying a preferred liver transplant donor. The method includes the step of determining in an individual the presence or absence of a preferred genotype at a polymorphic site, where the preferred genotype is associated with altered activity of a tumor necrosis factor, and wherein the presence of the preferred genotype indicates that the individual is a preferred liver transplant donor. A preferred genotype can be associated with lower activity of a tumor necrosis factor such as TNF-α and can be, for example, TNF308.1. The methods of the invention are useful for identifying a preferred donor liver for transplant into a HCV infected patient. The invention additionally provides a method for selecting a preferred liver for transplantation. The invention further provides a method for limiting the recurrence of HCV infection in a liver transplant recipient.
A method of identifying a preferred liver transplant donor, comprising determining in an individual the presence or absence of a preferred genotype at a polymorphic site, said preferred genotype associated with altered activity of a tumor necrosis factor, wherein the presence of said preferred genotype indicates that said individual is a preferred liver transplant donor.
A method for selecting a preferred liver for transplantation, comprising the steps of:
A method for limiting the severity of recurrence of hepatitis C in a liver transplant recipient, comprising the steps of:
Dependencies are inferred from the claim text.