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US 2002/0119453 A1Published application
HO-1 as a diagnostic and prognostic test for dementing diseases
OwnerHyman M. Schipper, Howard Chertkowinventors
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OwnerHyman M. Schipper, Howard Chertkowinventors
Estimating the term…
The invention relates to a commercial package for determining the concentration of heme oxygenase-1 (HO-1) and/or a nucleotide sequence encoding HO-1 in tissue obtained from a patient, wherein the commercial package is used to predict the onset of, diagnose, or prognosticate a dementing disease. The tissue is suitably plasma, lymphocytes, cerebrospinal fluid or fibroblasts. The commercial package is useful where the dementing disease is any of Alzheimer's Disease, Age-Associated Cognitive Decline, Progressive Supranuclear Palsy, Vascular (i.e. multi-infarct) Dementia, Lewy Body Dementia, Huntington's Disease, Down's syndrome, normal pressure hydrocephalus, corticobasal ganglionic degeneration, multisystem atrophy, head trauma, Creutzfeld-Jacob disease, viral encephalitis and hypothyroidism.
A commercial package comprising;
A commercial package comprising;
A commercial package comprising means for determining the concentration of heme oxygenase-1 (HO-1) and/or a nucleotide sequence encoding HO-1, in bodily fluid or tissue obtained from a patient, and instructions for comparing said concentration with an established standard of the corresponding concentration of HO-1 and/or an HO-1 encoding nucleotide sequence in corresponding bodily fluid or tissue obtained from at least one normal age-matched control person or from the patient at an earlier time.
Dependencies are inferred from the claim text.