CGI-69 compositions and methods of use
OwnerSean H. Adams, David Lewin +1inventors
InventorsSean H. Adams, David Lewin, Xing Xian Yu
Life of this patent
Estimating the term…
Abstract
An isolated polypeptide comprising an amino acid sequence having at least 80% sequence identity to the sequence SEQ ID NO:1, polynucleotides encoding these peptides, and antibodies to the polypeptides are useful in treating metabolic disorders or disorders associated with changes in adipose tissue physiological function or mass.
Claims34
An isolated CGI-69 nucleic acid comprising:
- (a) a nucleic acid sequence comprising at least 80% identity with SEQ ID NO:1, excluding the CGI-69 nucleic acid having the sequence of SEQ ID NO:2;
- or
- (b) a complement of the nucleic acid sequence of (a).
An isolated CGI-69 polypeptide comprising an amino acid sequence having at least 80% sequence identity to the sequence of SEQ ID NO:3, excluding the CGI-69 polypeptide having the sequence of SEQ ID NO:4.
A CGI-69 fusion protein comprising a polypeptide fused to the carboxy-terminus of a polypeptide comprising an amino acid sequence having at least 80% sequence identity to the sequence of SEQ ID NO:3.
A method of treating a metabolic disorder comprising modulating the activity of CGI-69.
A method for determining whether a compound up-regulates or down-regulates expression of a CGI-69 gene in a cell, comprising:
- (a) contacting the cell with said compound;
- and
- (b) detecting expression of the gene.
A transgenic non-human animal, having a disrupted CGI-69 gene.
A transgenic non-human animal, comprising a transgene having at least 80% sequence identity to the sequence of SEQ ID NO:1 or a complement of said sequence.
A method of screening for a mutation in CGI-69 comprising comparing a nucleic acid sequence to the sequence of SEQ ID Nos:1 or 2.
A method of measuring CGI-69 agonist or antagonist activity of a compound comprising:
- (a) contacting a composition comprising CGI-69 activity with the compound;
- and
- (b) determining a change in the CGI-69 activity.
Dependencies are inferred from the claim text.