Inhibitors of the JNK signal transduction pathway and methods of use
OwnerRoger J. Davis, Martin Dickensinventors
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Abstract
JNK-interacting protein 1 (JIP-1), an inhibitor of the JNK1 protein, and methods of treating a pathological condition or of preventing the occurrence of a pathological condition in a patient by the administration of a therapeutically effective amount of JIP-1 polypeptides, peptides, peptide mimetics, or nucleic acids are described.
Claims27
A substantially pure JNK-interacting protein 1 (JIP-1) polypeptide or a biologically active fragment thereof.
A method of treating a patient having a pathological condition associated with abnormal expression or activity of JNK, or at risk of developing a pathological condition associated with abnormal activity or expression of JNK, said method comprising administering to the patient a therapeutically effective amount of a JIP-1 nucleic acid.
A method of treating a patient having a pathological condition associated with abnormal expression or activity of JNK, or at risk of developing a pathological condition associated with abnormal activity or expression of JNK, said method comprising administering to the patient a therapeutically effective amount of a JIP-1 polypeptide.
Dependencies are inferred from the claim text.