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AssigneesProteome Sciences plc, Bruce M. Cameron, Sr.
InventorsBruce M. Cameron SR., Robert C. Allen
Estimating the term…
The present invention provides novel methods and diagnostic kits for the objective measurement of the severity of pain or stress being experienced by a patient with a disorder, diagnosis and treatment for patients suffering from painful disorders, and monitoring the effectiveness of different pain-treatment protocols. Pain-measuring methods comprise collecting a sample from a patient and determining the presence of a pain-associated marker in the sample. Methods for alleviating pain comprise administrating a dose of a therapeutically effective amount of a composition to the patient wherein the dose is determined by the presence of a pain-associated marker in a biological sample obtained from the patient. Compositions for alleviating pain comprise substances that are pain-associated markers or agents that interfere with pain-associated markers, and block or modulate the progression of pain perceived by the patient.
A method of diagnosing the intensity of a pain perceived by a patient comprising determining the amount of a marker in a biological sample obtained from said patient wherein said marker correlates with the perception of the pain.
A method of determining the intensity of a pain perceived by a patient comprising the steps of:
A method for determining the intensity of a pain perceived by a patient by determining the amount of cholinesterase in a sample of body fluid obtained from the patient.
A method for determining the level of stress perceived by an individual comprising:
The method of claim 19 wherein the marker is cholinesterase.
A method for identifying a marker that correlates with the intensity of a pain perceived by a patient comprising the steps of:
A method for determining the efficacy of a treatment for pain comprising:
A diagnostic kit for determining the severity of a pain in a patient comprising at least one agent that reacts with a marker whose presence in a biological sample correlates with the perception of the pain in a patient from whom the sample is obtained.
A pharmaceutical composition comprising a pain-associated marker that selectively inhibits the perception of pain when administered to a patient.
A pharmaceutical composition comprising an agent that selectively inhibits the activity of a pain-associated marker.
A method of treating a pain perceived by a patient comprising:
A method of modulating the amount of pain perceived by a patient comprising:
A method of modulating the amount of a pain perceived by a patient comprising:
Dependencies are inferred from the claim text.