Alpha 1-antitrypsin preparation as well as a method for producing the same
AssigneeBaxter Aktiengesellschaft
InventorsErwin Mattes, H. Peter Matthiessen
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Abstract
A native, chromatographically purified α1-AT preparation having a purity of at least 0.7 PU/mg protein and a relative plasma α1-AT activity of at least 120% is disclosed. The ratio of active to inactive α1-AT is higher than in plasma. Furthermore, a method of producing this preparation is disclosed, as well as the use of a carrier material, e.g. an inorganic carrier material such as hydroxylapatite for separating active α1-AT from inactive α1-AT.
Claims9
A native chromatographically purified α1-AT preparation, characterized in that it contains at least the isomer having a pI value of between 4.3 and 4.4, has a purity of at least 0.7 PU/mg protein and a relative plasma-α1-AT activity of at least 120% and that its portion of inactive α1-AT is less than 10%.
Dependencies are inferred from the claim text.