pCAR and its uses
AssigneeNovartis AG
InventorsThomas Buhler, Reto Andreas Gadient, Reinhard Korn, Rao Movva
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Abstract
The invention provides improvements in the field of animal models for testing effects of genes introduced into animal cells or tissue by adenoviral gene transfer. More particularly the invention provides a plasmid construct that expresses a porcine adenovirus receptor (pCAR) and transgenic animals that show expression of pCAR.
Claims25
A C-terminally truncated porcine CAR or a fragment or variant thereof which mediates adenoviral transduction.
A plasmid or vector construct that comprises a DNA molecule which expresses a porcine CAR or a fragment or variant thereof which mediates adenoviral transduction.
Dependencies are inferred from the claim text.