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OwnerMichael A. Lonetto, David J. Holmes +9inventors
InventorsMichael A. Lonetto, David J. Holmes, Deborah D. Jaworski, Richard O. Nicholas, Min Wang, Robert K. Stodola, Anna L. Kosmatka, Richard L. Warren, David J.C. Knowles, Christopher M. Traini, John E. Hodgson
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The invention provides def1 polypeptides and polynucleotides encoding def1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing def1 polypeptides to screen for antibacterial compounds.
An isolated polynucleotide comprising a polynucleotide having at least a 70% identity to a polynucleotide encoding a polypeptide comprising the amino acid sequence of SEQ ID NO:2.
An isolated polynucleotide comprising a polynucleotide having at least a 70% identity to a polynucleotide encoding the same mature polypeptide expressed by the def1 gene contained in the Streptococcus pneumoniae of the deposited strain.
An isolated polynucleotide comprising a polynucleotide encoding a polypeptide comprising an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID NO:2.
A polypeptide comprising an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID NO:2.
A polypeptide comprising an amino acid sequence as set forth in SEQ ID NO:2.
An isolated polynucleotide comprising a polynucleotide having at least a 70% identity to a polynucleotide encoding a polypeptide comprising the amino acid sequence of SEQ ID NO:4.
An isolated polynucleotide comprising a polynucleotide having at least a 70% identity to the polynucleotide sequence of SEQ ID NO:3.
Dependencies are inferred from the claim text.