Powder containing physiologically active peptide
AssigneeJCR PHARMACEUTICALS CO., Lrd.
InventorsYoshinobu Hanyu, Mariko Okada, Chihiro Shindo, Satoshi Nishimuro, Tetsuo Yokoyama, Masato Horie
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Abstract
A method is disclosed for stabilizing a physiologically active peptide in a process of preparing a powder containing the physiologically active peptide by drying an aqueous liquid containing the physiologically active peptide, wherein the method comprises adding to the aqueous liquid at least one compound selected from the group consisting of a nonionic surfactant, a water-soluble, nonionic, organic binder, hydrogenated lecithin, and mannitol.
Claims32
A method for stabilization of a physiologically active peptide in a process of preparing a powder containing the physiologically active peptide by drying an aqueous liquid containing the physiologically active peptide, wherein the method comprises adding to the aqueous liquid at least one compound selected from the group consisting of a nonionic surfactant, a water-soluble, nonionic, organic binder, hydrogenated lecithin, and mannitol.
A method for stabilization of a physiologically active peptide in a process of preparing a powder containing the physiologically active peptide by drying an aqueous liquid containing the physiologically active peptide, wherein the method comprises adding to the aqueous liquid mannitol and at least one compound selected from the group consisting of a nonionic surfactant, a water-soluble, nonionic, organic binder, and hydrogenated lecithin.
A method for stabilization of a physiologically active peptide in a process of preparing a powder containing the physiologically active peptide by drying an aqueous liquid containing the physiologically active peptide, wherein the method comprises adding to the aqueous liquid at least one component selected from the group consisting of a nonionic surfactant in an amount of 0.01-0.5% by weight, a water-soluble, nonionic, organic binder in an amount of 0.01-1% by weight, hydrogenated lecithin, and 1-50 parts by weight of mannitol per one part by weight of the physiologically active peptide.
A method for stabilization of a physiologically active peptide in a process of preparing a powder containing the physiologically active peptide by drying an aqueous liquid containing the physiologically active peptide, wherein the method comprises adding to the aqueous liquid 1-50 parts by weight of mannitol per one part by weight of the physiologically active peptide and at least one component selected from the group consisting of a nonionic surfactant in an amount of 0.01-0.5% by weight, a water-soluble, nonionic, organic binder in an amount of 0.01-1% by weight, and hydrogenated lecithin.
A method for preparation of a powder containing a physiologically active peptide, wherein the method comprises forming a powder by drying an aqueous liquid containing a physiologically active peptide and at least one compound selected from the group consisting of a nonionic surfactant, a water-soluble, nonionic, organic binder, hydrogenated lecithin, and mannitol.
A method for preparation of a powder containing a physiologically active peptide, wherein the method comprises forming a powder by drying an aqueous liquid containing the physiologically active peptide., mannitol, and at least one compound selected from the group consisting of a nonionic surfactant, a water-soluble, nonionic, organic binder, and hydrogenated lecithin.
A method for preparation of a powder containing a physiologically active peptide, wherein the method comprises forming a powder by drying an aqueous liquid containing the physiologically active peptide and at least one component selected from the group consisting of a nonionic surfactant in an amount of 0.01-0.5% by weight, a water-soluble, nonionic, organic binder in an amount of 0.01-1% by weight, hydrogenated lecithin and 1-50 parts by weight of mannitol per one part by weight of the physiologically active peptide.
A method for preparation of a powder containing a physiologically active peptide, wherein the method comprises forming a powder by drying an aqueous liquid containing the physiologically active peptide, 1-50 parts by weight of mannitol per one part by weight of the physiologically active peptide, and at least one component selected from the group consisting of a nonionic surfactant in an amount of 0.01-0.5% by weight, a water-soluble, nonionic, organic binder in an amount of 0.01-1% by weight, and hydrogenated lecithin.
A powder containing a physiologically active peptide, wherein the powder is made up of particles comprising a physiologically active peptide and mannitol at a weight proportion of 1:1 to 1:50.
Dependencies are inferred from the claim text.