Cell growth regulation system
AssigneePhoenix Pharmaceuticals, Inc.
InventorJaw-Kang Chang
Life of this patent
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Abstract
Stable water soluble polypeptides which are potent inhibitors of endothelial cell proliferation and of angiogenesis. Polypeptide inhibitors of endothelial cell growth may have important uses in the elucidation of the mechanism of angiogenesis, disease diagnosis and prognostication, and drug therapies for use in animals and humans.
Claims12
A purified polypeptide the amino acid sequence of which consists of SEQ ID NO:1.
A purified polypeptide the amino acid sequence of which comprises at least eight consecutive residues of SEQ ID NO:1.
A purified polypeptide the amino acid sequence of which comprises residues 33-63 of SEQ ID NO:1.
A purified polypeptide the amino acid sequence of which comprises consecutive residues of SEQ ID NO:1 selected from the group consisting of 34-63, 35-63, 36-63, 37-63, 38-63, 39-63, 40-63, 41-63, 42-63, 43-63, 44-63, 45-63, 46-63, 47-48-63, 49-63, 50-63, 51-63, 52-63, 53-63, 54-63, 55-63, and 56-63.
A method of reducing tumor volume in an animal, comprising introducing into the animal a purified polypeptide the amino acid sequence of which comprises at least eight consecutive residues of SEQ ID NO:1.
A method of inhibiting the proliferation of endothelial cells in an animal, comprising introducing into the animal a purified polypeptide the amino acid sequence of which comprises at least eight consecutive residues of SEQ ID NO:1.
A method of targeting and binding a purified polypeptide to an angiogenesis receptor, comprising introducing into the animal a purified polypeptide the amino acid sequence of which comprises at least eight consecutive residues of SEQ ID NO:1.
A kit comprising at least one vessel containing a purified polypeptide the amino acid sequence of which comprises at least eight consecutive residues of SEQ ID NO:1.
Dependencies are inferred from the claim text.