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AssigneeMassachusetts Institute of Technology
InventorsGerald E. Schneider, Dong Feng Chen, Susumu Tonegowa, Sonal Jhaveri
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Agents which modulate a bcl family member to control axonal growth and regeneration are described. These bcl modulating agents promote axonal growth and regeneration in the neural cells of a subject. Compositions for promoting axonal cell growth in a subject also are described. The compositions of the present invention include an effective amount of an agent which modulates a bcl family member and in a pharmaceutically acceptable carrier. Other described aspects include packaged drugs for treating a state characterized by diminished potential for axonal growth. The packaged compounds and agents also include instructions for using the agent to promote axonal growth in a subject.
A method of promoting axonal growth in a neural cell, comprising modulating the expression or bioactivity of a bcl family member in a neural cell such that axonal growth occurs.
A method of treating a subject that has suffered a traumatic injury in which nerve cell injury has occurred, comprising administering to said subject a bcl modulating agent such that treatment of the traumatic injury occurs.
A method of treating a subject for a state characterized by diminished potential for axonal growth, comprising administering a therapeutically effective amount of an agent which modulates the bioactivity or expression of a bcl family member in a subject such that axonal growth occurs.
A method of treating a state characterized by diminished potential for axonal growth, comprising administering to a subject with said state a therapeutically effective amount of a gene construct for expressing a bcl-2 family member, wherein the gene construct is formulated for delivery into neural cells of the subject such that axonal growth occurs.
A pharmaceutical preparation comprising a therapeutically effective amount of a recombinant transfection system for treating a state associated with diminished potential for axonal growth in a subject, comprising
A packaged drug for treating a state associated with diminished potential for axonal growth, comprising a bcl-2 modulating agent packaged with instructions for treating a subject having said state.
A method for selecting an agent for its ability to promote axonal growth in a culture comprising;
A method for selecting an agent for its ability to promote axonal growth in a culture comprising;
Dependencies are inferred from the claim text.