Bioactive surgical suture
OwnerTerry Y. Shibuyainventor
Life of this patent
Estimating the term…
Abstract
The application concerns surgical suture coated with one or more biologically active compounds. The application discloses methods of making coated suture, placing the coated suture in an organism, and methods of using the coated suture in the treatment of diseases such as cancer.
Claims48
A method of coating surgical suture with a biologically active compound comprising:
- placing a length of surgical suture into a solution comprising the biologically active compound;
- and
- incubating the suture in the solution until the biologically active compound is bound to the suture.
A method of placing a surgical suture coated with one or more biologically active compounds into a patient comprising:
- passing a needle with a trochar into the desired location in the patient;
- removing the trochar;
- passing the suture down the barrel of the needle;
- removing the needle over the suture while leaving the suture in position.
A method of reducing rejection of transplanted organs comprising placing a suture coated with an immunosuppressive compound into the organ bed or regional lymphatics of a patient receiving a donor organ.
A surgical suture coated with at least one biologically active compound.
A method of treating a patient suffering from a disease that is characterized by suppression of the immune system comprising placing a suture coated with one or more immuno-stimulating compounds into a lymph node in the patient.
A method of treating a patient suffering from head and neck cancer comprising:
- placing a first suture coated with human defensin into a palpable regional lymph node;
- and
- placing a second suture coated with anti-CD3 and anti-CD28 antibodies into a palpable regional lymph node.
A method of adoptive immunotherapy comprising:
- placing a suture coated with one or more immuno-stimulating molecules into the lymph node of a patient;
- removing the lymph node of the patient;
- expanding the lymph-node lymphocytes in vitro;
- and
- infusing the expanded lymphocytes into the patient.
A method of expanding lymphocytes in vitro comprising contacting the lymphocytes with surgical suture coated with anti-CD3 and anti-CD28.
A method of treating cancer in a patient comprising:
- surgically resecting the tumor;
- and
- placing a suture coated with an immuno-modulating compound in the floor of the wound created by the resection.
Dependencies are inferred from the claim text.