Aspirin-triggered lipid mediators
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsCharles N. Serhan, Clary B. Clish
Life of this patent
Estimating the term…
Abstract
Aspirin triggered lipid mediators (ATLMs) are disclosed which are useful for the treatment of prevention of inflammation associated with various diseases, including ischemia.
Claims39
A compound having the formula:
- 12
- wherein R is a hydrogen atom or a pharmaceutically acceptable salt, ester, amide or prodrug and wherein P is a hydrogen atom or a protecting group.
A compound having the formula:
- 13
- wherein R is a hydrogen atom or a pharmaceutically acceptable salt, ester, amide or prodrug and wherein P is a hydrogen atom or a protecting group.
A compound having the formula:
- 14
- wherein R is a hydrogen atom or a pharmaceutically acceptable salt, ester, amide or prodrug and wherein one or more P's are hydrogen atoms or one or more protecting groups or combinations thereof.
A compound having the formula:
- 15
- wherein R is a hydrogen atom or a pharmaceutically acceptable salt, ester, amide or prodrug and wherein one or more P's are hydrogen atoms or protecting groups or combinations thereof.
A method for treating or preventing inflammation in a subject, comprising the step of administering a combination of an omega-3 fatty acid and aspirin, such that inflammation is treated or prevented in the subject.
A method for treating arterial inflammation, arthritis, or cardiovascular diseases in a subject, comprising the step of administering to the subject a combination of an omega-3 fatty acid and aspirin, such that arterial inflammation, arthritis, or cardiovascular disease is treated or prevented in the subject.
A method for treating or preventing inflammation in a subject, comprising the step of administering to the subject a compound having the formula:
- 16
- wherein R is a hydrogen atom or is a pharmaceutically acceptable salt, ester, amide or prodrug and wherein P is a hydrogen atom or a protecting group, such that inflammation is treated or prevented in the subject.
A method for treating or preventing inflammation in a subject, comprising the step of administering to the subject a compound having the formula:
- 17
- wherein R is a hydrogen atom or a pharmaceutically acceptable salt, ester, amide or prodrug and wherein P is a hydrogen atom or a protecting group, such that inflammation is treated or prevented in the subject.
A method for treating or preventing inflammation in a subject, comprising the step of administering to the subject a compound having the formula:
- 18
- wherein R is a hydrogen atom or a pharmaceutically acceptable salt, ester, amide or prodrug and wherein one or more P's are hydrogen atoms or one or more protecting groups or combinations thereof, such that inflammation is treated or prevented in the subject.
A method for treating or preventing inflammation in a subject, comprising the step of administering to the subject a compound having the formula:
- 19
- wherein R is a hydrogen atom or a pharmaceutically acceptable salt, ester, amide or prodrug and wherein one or more P's are hydrogen atoms or one or more protecting groups or combinations thereof, such that inflammation is treated or prevented in the subject.
A method for treating arterial inflammation, arthritis, or cardiovascular diseases in a subject, comprising the step of administering to the subject compound having the formula:
- 20
- wherein R is a hydrogen atom or a pharmaceutically acceptable salt, ester, amide or prodrug and wherein P is a hydrogen atom or a protecting group, such that arterial inflammation, arthritis, or cardiovascular disease is treated or prevented in the subject.
A method for treating arterial inflammation, arthritis, or cardiovascular diseases in a subject, comprising administering to the subject a compound having the formula:
- 21
- wherein R is a hydrogen atom or a pharmaceutically acceptable salt, ester, amide or prodrug and P is a hydrogen atom or a protecting group, such that arterial inflammation, arthritis, or cardiovascular disease is treated or prevented in the subject.
A method for treating arterial inflammation, arthritis, or cardiovascular diseases in a subject, comprising administering to the mammal a compound having the formula:
- 22
- wherein R is a hydrogen atom or a pharmaceutically acceptable salt, ester, amide or prodrug and wherein one or more P's are hydrogen atoms or one or more protecting groups or combinations thereof, such that arterial inflammation, arthritis, or cardiovascular disease is treated or prevented in the subject.
A method for treating arterial inflammation, arthritis, or cardiovascular diseases in a subject, comprising administering to the mammal a compound having the formula:
- 23
- wherein R is a hydrogen atom or a pharmaceutically acceptable salt, ester, amide or prodrug and wherein one or more P's are hydrogen atoms or one or more protecting groups or combinations thereof, such that arterial inflammation, arthritis, or cardiovascular disease is treated or prevented in the subject.
A hydroxyl protected or unprotected monohydroxyl-docosahexaenoic acid or a pharmaceutically acceptable analogue thereof.
A compound having the formula:
- 24
- wherein R is a hydrogen atom or a pharmaceutically acceptable salt, ester, amide or prodrug and wherein P is a hydrogen atom or a protecting group.
A compound having the formula:
- 25
- wherein R is a hydrogen atom or a pharmaceutically acceptable salt, ester, amide or prodrug and wherein P is a hydrogen atom or a protecting group.
A compound having the formula:
- 26
- wherein R is a hydrogen atom or a pharmaceutically acceptable salt, ester, amide or prodrug and wherein P is a hydrogen atom or a protecting group.
A compound having the formula:
- 27
- wherein R is a hydrogen atom or a pharmaceutically acceptable salt, ester, amide or prodrug and wherein P is a hydrogen atom or a protecting group.
A compound having the formula:
- 28
- wherein R is a hydrogen atom or a pharmaceutically acceptable salt, ester, amide or prodrug and wherein P is a hydrogen atom or a protecting group.
A compound having the formula:
- 29
- wherein R is a hydrogen atom or a pharmaceutically acceptable salt, ester, amide or prodrug and wherein P is a hydrogen atom or a protecting group.
A method for treating or preventing inflammation in a subject, comprising the step of administering to the subject a compound having the formula:
- 30
- wherein R is a hydrogen atom or a pharmaceutically acceptable salt, ester, amide or prodrug and wherein P is a hydrogen atom or a protecting group, such that the subject is treated.
A method for treating or preventing inflammation in a subject, comprising the step of administering to the subject a compound having the formula:
- 31
- wherein R is a hydrogen atom or a pharmaceutically acceptable salt, ester, amide or prodrug and wherein P is a hydrogen atom or a protecting group, such that the subject is treated.
A method for treating or preventing inflammation in a subject, comprising the step of administering to the subject a compound having the formula:
- 32
- wherein R is a hydrogen atom or a pharmaceutically acceptable salt, ester, amide or prodrug and wherein P is a hydrogen atom or a protecting group, such that the subject is treated.
A method for treating or preventing inflammation in a subject, comprising the step of administering to the subject a compound having the formula:
- 33
- wherein R is a hydrogen atom or a pharmaceutically acceptable salt, ester, amide or prodrug and wherein P is a hydrogen atom or a protecting group, such that the patient is treated.
A method for treating or preventing inflammation in a subject, comprising the step of administering to the subject a compound having the formula:
- 34
- wherein R is a hydrogen atom or a pharmaceutically acceptable salt, ester, amide or prodrug and wherein P is a hydrogen atom or a protecting group, such that the subject is treated.
A method for treating or preventing inflammation in a subject, comprising the step of administering to the subject a compound having the formula:
- 35
- wherein R is a hydrogen atom or a pharmaceutically acceptable salt, ester, amide or prodrug and wherein P is a hydrogen atom or a protecting group, such that the subject is treated.
Dependencies are inferred from the claim text.