Macrolide antiinfective agents

A compound of the formula

• 46
• wherein
• Ra is substituted or unsubstituted alkyl (1-10C);
• substituted or unsubstituted alkenyl (2-10C);
• substituted or unsubstituted alkynyl (2-10C);
• substituted or unsubstituted aryl;
• substituted or unsubstituted arylalkyl;
• or ORa is replaced by H;
• Rb is H or halogen;
• Rc is H or a protecting group;
• Rd′ is H, substituted or unsubstituted alkyl (1-10C);
• substituted or unsubstituted alkenyl (2-10C);
• substituted or unsubstituted alkynyl (2-10C);
• substituted or unsubstituted aryl (3-10C);
• substituted or unsubstituted arylalkyl (4-10C);
• substituted or unsubstituted arylalkynyl (5-20C);
• substituted or unsubstituted amidoarylalkyl (5-20C);
• substituted or unsubstituted amidoarylalkenyl (5-20C);
• or substituted or unsubstituted amidoarylalkynyl (5-20C);
• Re is H or a protecting group;
• L is methylene or carbonyl;
• T is —O—, —N(R)—, or —N(OR)—, —N(NHCOR)—, —N(N═CHR)—, or —N(NHR)— wherein R is H or Ra as defined above, with the proviso that when L is methylene, T is —O—;
• one of Z and Y is H and the other is OH, protected OH, or amino, mono- or dialkylamino, protected amino, or an amino heterocycle or
• Z and Y together are ═O, ═NOH or a derivatized oxime;
• including any pharmaceutically acceptable salts thereof and any stereoisomeric forms and mixtures of stereoisomeric forms thereof.