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AssigneeInstitut Pasteur
InventorsJuerg Gysin, Bruno Pouvelle, Artur Scherf, Pierre Buffet
Estimating the term…
The present invention provides the RSP-1 and RSP-2 proteins which are involved in the cytoadhesion of P. falciparum during ring-stage infection of erythrocytes, antibodies which bind to the proteins, methods of screening for a P. falciparum infection, methods of determining the infective stage of P. falciparum and vaccines for protecting individuals from Plasmodium sp. infections.
An isolated protein which mediates Plasmodium falciparum ring-stage adhesion to endothelial cells and is approximately 200 kilodaltons in size as determined by SDS-polyacrylamide gel electrophoresis.
An isolated protein which mediates Plasmodium falciparum ring-stage adhesion to endothelial cells and is approximately 40 kilodaltons in size as determined by SDS-polyacrylamide gel electrophoresis.
A composition comprising at least one of the isolated proteins RSP-1 and RSP-2 and a pharmaceutical acceptable carrier.
A method of protecting an individual against a Plasmodium falciparum infection comprising:
Hybridoma Pf 26G1/B4 deposited at the C.N.C.M under the accession number I-2635.
Dependencies are inferred from the claim text.