Methods for detecting nucleic acid molecules encoding flh2882, a GPCR showing homology to the 5HT family of receptors

An isolated protein selected from the group consisting of:

• a) a protein comprising the amino acid sequence of SEQ ID NO:2;
• b) a fragment of a protein comprising the amino acid sequence of SEQ ID NO:2, wherein the fragment comprises at least 15 contiguous amino acids of SEQ ID NO:2;
• and
• c) a naturally occurring allelic variant of a protein comprising the amino acid sequence of SEQ ID NO:2, wherein the protein is encoded by a nucleic acid molecule which hybridizes to a nucleic acid molecule comprising SEQ ID NO:1 under stringent conditions.

A method for detecting the presence of a protein selected from the group consisting of:

• a) a protein comprising the amino acid sequence of SEQ ID NO:2;
• b) a fragment of a protein comprising the amino acid sequence of SEQ ID NO:2, wherein the fragment comprises at least 15 contiguous amino acids of SEQ ID NO:2;
• and
• c) a naturally occurring allelic variant of a protein comprising the amino acid sequence of SEQ ID NO:2, wherein the protein is encoded by a nucleic acid molecule which hybridizes to a nucleic acid molecule comprising SEQ ID NO:1 under stringent conditions;
• in a sample, the method comprising the steps of:
• i) contacting the sample with a compound which selectively binds to the protein;
• and
• ii) determining whether the compound binds to the protein in the sample.

A method for detecting the presence of a nucleic acid molecule selected from the group consisting of:

• a) a nucleic acid molecule which encodes a protein comprising the amino acid sequence of SEQ ID NO:2;
• b) a nucleic acid molecule which encodes a fragment of a protein comprising the amino acid sequence of SEQ ID NO:2, wherein the fragment comprises at least 15 contiguous amino acids of SEQ ID NO:2;
• and
• c) a nucleic acid molecule which encodes a naturally occurring allelic variant of a protein comprising the amino acid sequence of SEQ ID NO:2, wherein the nucleic acid molecule hybridizes to a nucleic acid molecule comprising SEQ ID NO:1 under stringent conditions;
• in a sample, the method comprising the steps of:
• i) contacting the sample with a nucleic acid probe or primer which selectively hybridizes to the nucleic acid molecule;
• and
• ii) determining whether the nucleic acid probe or primer binds to a nucleic acid molecule in the sample.

A method for identifying a compound which binds to a protein selected from the group consisting of:

• a) a protein comprising the amino acid sequence of SEQ ID NO:2;
• b) a fragment of a protein comprising the amino acid sequence of SEQ ID NO:2, wherein the fragment comprises at least 15 contiguous amino acids of SEQ ID NO:2;
• and
• c) a naturally occurring allelic variant of a protein comprising the amino acid sequence of SEQ ID NO:2, wherein the protein is encoded by a nucleic acid molecule which hybridizes to a nucleic acid molecule comprising SEQ ID NO:1 under stringent conditions,
• the method comprising the steps of:
• i) contacting the protein, or a cell expressing the protein with a test compound;
• and
• ii) determining whether the protein binds to the test compound.

A method for modulating the activity of a protein selected from the group consisting of:

• a) a protein comprising the amino acid sequence of SEQ ID NO:2;
• and
• b) a naturally occurring allelic variant of a protein comprising the amino acid sequence of SEQ ID NO:2, wherein the protein is encoded by a nucleic acid molecule which hybridizes to a nucleic acid molecule comprising SEQ ID NO:1 under stringent conditions,
• the method comprising the steps of:
• i) contacting a cell expressing the protein with a compound which binds to the protein in a sufficient concentration to modulate the activity of the protein.