Melanoma and prostate cancer specific antibodies for immunodetection and immunotherapy
OwnerJuergen R. Vielkindinventor
Life of this patent
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Abstract
Methods and compositions are provided for detecting antigens having a specific epitope associated with melanoma and prostatic carcinoma. The epitope is present in melanoma cells and prostatic cancer cells but is essentially absent from melanocytes and normal prostatic tissue. The antibody can be used in diagnostic methods for histochemical detection of human melanoma and prostate carcinoma, of various progression stages and in treatment of melanoma and prostate carcinoma.
Claims20
A method for detecting the presence of melanoma or prostatic cancer in a human host, said method comprising:
- combining a sample from said human host with antibodies or antibody fragments which bind specifically to a peptide having the amino acid sequence depicted in SEQ ID NO:1, and detecting formation of immune complexes as indicative of the presence of melanoma cells or prostatic cancer cells.
A method for detecting high grade prostate intraepithelial neoplasia in a human host, said method comprising:
- combining a sample from said human host with antibodies or antibody fragments which bind specifically to a peptide having the amino acid sequence depicted in SEQ ID NO:
- 1, and detecting formation of immune complexes as indicative of the presence of high grade prostate intraepithelial neoplasia.
A method for early detection of prostate carcinoma, said method comprising:
- combining a sample from said human host with antibodies or antibody fragments which bind specifically to a peptide having the amino acid sequence depicted in SEQ ID NO:
- 1, and detecting formation of immune complexes as an early indication of the presence of prostate carcinoma
A method for treating human melanoma or prostate cancer, said method comprising:
- administering a therapeutic dose of a conjugate comprising a monoclonal antibody or monoclonal antibody fragment, which binds specifically to a peptide having the amino acid sequence depicted in SEQ ID NO:
- 1, and a cytotoxic agent.
A kit for screening a sample to detect melanoma or prostate cancer cells, said kit comprising:
- (a) an antibody or an antibody fragment, which binds specifically to a peptide having the amino acid sequence depicted in SEQ ID NO:
- 1;
- and
- (b) means for detecting the reaction of said antibody or said antibody fragment with said melanoma cells or said prostate cancer cells.
A peptide comprising an amino acid sequence characterized as (1) present in the extracellular domain of a polypeptide encoded an the mrk gene of Xiphophorus, and (2) reactive with antibodies obtained from hybridoma cell line 12f3.2.
An antigen which binds to antibodies obtained from hybridoma cell line 12f3.2.
Dependencies are inferred from the claim text.