Fluidized bed matrix granule
AssigneeGenecor International, Inc.
InventorsNATHANIEL T. BECKER, ROBERT I. CHRISTENSEN JR., ERNST H. GROS
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Abstract
Granules that include a protein core are described. The protein core includes a protein matrix which includes a protein mixed together with a salt. The protein matrix is layered over a seed particle. The protein can be an enzyme or a therapeutic protein such as a hormone. Methods of making the granules are also described.
Claims27
A granule comprising a protein core comprising a protein matrix layered over a seed particle, wherein the protein matrix comprises a protein mixed together with a salt.
A granule comprising an enzyme core comprising an enzyme matrix layered over a seed particle, wherein the enzyme matrix comprises an enzyme mixed together with a salt.
A method of making a granule comprising:
- a. fluidizing seed particles in a fluid-bed coater;
- b. providing a protein matrix formula comprising a protein mixed together with a salt;
- and
- c. spraying the protein matrix formula on the seed particles.
Dependencies are inferred from the claim text.