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US 2002/0001574 A1Published application
Process of delivering a polynucleotide to a muscle cell via the vascular system
OwnerJon A. Woiff, Stuart J. Knechtle +1inventors
InventorsJON A. WOIFF, STUART J. KNECHTLE, VLADIMIR BUDKER
Life of this patent
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Abstract
A process for delivering a polynucleotide into a parenchymal cell in a mammal, comprising, transporting the polynucleotide into a blood vessel communicating with the parenchymal cell in tissue or organ of the mammal such that the polynucleotide is transfected into the parenchymal cell. More specifically, the parenchymal cell consists of a muscle cell and the polynucleotide consists of a viral vector.
Claims18
A process for delivering a polynucleotide to a muscle cell, comprising:
- inserting the polynucleotide into a vessel for delivery to the muscle cell such that the polynucleotide is transfected into the muscle cell.
A process for delivering a polynucleotide to a muscle cell for expressing a protein, comprising:
- a) inserting the polynucleotide into a vessel having a permeable wall;
- and,
- b) increasing the permeability of the wall for a time sufficient to allow delivery of the polynucleotide.
Dependencies are inferred from the claim text.